{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:17:23Z","timestamp":1792761443686,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR 2093"],"award-info":[{"award-number":["FOR 2093"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 654"],"award-info":[{"award-number":["SFB 654"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Day\u2010to\u2010day life involves the perception of events that resemble one another. For the sufficient encoding and retrieval of similar information, the hippocampus provides two essential computational processes. Pattern separation refers to the differentiation of overlapping memory representations, whereas pattern completion reactivates memories based on noisy or degraded input. Evidence from human and rodent studies suggest that pattern separation specifically relies on neuronal ensemble activity in hippocampal subnetworks in the dentate gyrus and CA3. Although a role for CA1 in pattern separation has been shown in animal models, its contribution in the human hippocampus remains elusive. In order to elucidate the contribution of CA1 neurons to pattern separation, we examined 14 patients with an acute transient global amnesia (TGA), a rare self\u2010limiting dysfunction of the hippocampal system showing specific lesions to CA1. Patients' pattern separation performance was tested during the acute amnestic phase and follow\u2010up using an established mnemonic similarity test. Patients in the acute phase showed a profound deficit in pattern separation (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) as well as recognition memory (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) that recovered during follow\u2010up. Specifically, patients tested in a later stage of the amnesia were less impaired in pattern separation than in recognition memory. Considering the time dependency of lesion\u2010associated hippocampal deficits in early and late acute stages of the TGA, we showed that the pattern separation function recovered significantly earlier than recognition memory. Our results provide causal evidence that hippocampal CA1 neurons are critical to pattern separation performance in humans.<\/jats:p>","DOI":"10.1002\/hipo.23073","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T07:59:33Z","timestamp":1549007973000},"page":"736-747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Transient hippocampal CA1 lesions in humans impair pattern separation performance"],"prefix":"10.1002","volume":"29","author":[{"given":"Annika","family":"Hanert","sequence":"first","affiliation":[{"name":"Memory Disorders and Plasticity Group, Department of Neurology University Hospital Schleswig\u2010Holstein, Kiel, University of Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anya","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Psychology Clinical Psychology and Psychotherapy, University of Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8387-5731","authenticated-orcid":false,"given":"Thorsten","family":"Bartsch","sequence":"additional","affiliation":[{"name":"Memory Disorders and Plasticity Group, Department of Neurology University Hospital Schleswig\u2010Holstein, Kiel, University of Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22162"},{"key":"e_1_2_6_3_1","volume-title":"Regensburger Wortfl\u00fcssigkeitstest","author":"Aschenbrenner S.","year":"2000"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.07.081"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152882"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21189"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl248"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70344-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.137"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188160"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0518-16.2016"},{"key":"e_1_2_6_12_1","first-page":"205","volume-title":"Handbook of clinical neurology","author":"Caplan L.","year":"1985"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00202.2010"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.06.008"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20933"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0521-14.2014"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-33603-4"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.11.003"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1189-17.2017"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.119.1.342"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.53.10.834"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.09.014"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.11.015"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012547626-3\/50024-7"},{"key":"e_1_2_6_25_1","volume-title":"The Oxford handbook of comparative cognition","author":"Kesner R. 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