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Previously, we showed that dendrites of DH and VH pyramidal neurons of female rats are still developing robustly during adolescence and are altered by the experience of food restriction and voluntary exercise on a wheel. We tested whether such anatomical changes during adolescence impact anxiety\u2010like behavior and spatial cognition. Four groups of female rats were evaluated for these behaviors: those with wheel access in its cage from postnatal day (P) 36\u201344 (EX); those with food access restricted to 1 hr per day, from P40 to 44 (FR); those with EX from P36 to 44, combined with FR from P40 to 44, which we will refer to as EX\u2009+\u2009FR; and controls, CON (no EX, no FR). Open field test for anxiety\u2010like behavior and active place avoidance test for spatial cognition were conducted at P47\u201349, the age when food restricted animals have restored body weight, or at P54\u201356, to identify more enduring effects. Anxiety\u2010like behavior was elevated for the EX and FR groups at P47\u201349 but not for the EX\u2009+\u2009FR group. By P54\u201356, the EX\u2009+\u2009FR and EX groups exhibited less anxiety\u2010like behavior, indicating a beneficial delayed main effect of exercise. There was a beneficial main effect of food restriction upon cognition, as the FR group showed cognition superior to CONs' at P44\u201346 and P54\u201356, while the EX\u2009+\u2009FR animals also showed enhanced spatial learning at P54\u201356. EX\u2009+\u2009FR animals with best adaptation to the feeding schedule showed the best spatial learning performance but with a delay. The EX group exhibited only a transient improvement. These findings indicate that FR, EX, and EX\u2009+\u2009FR in mid\u2010adolescence are all beneficial in reducing anxiety\u2010like behavior and improving spatial cognition but with subtle differences in the timing of their manifestation, possibly reflecting the protracted maturation of the hippocampus.<\/jats:p>","DOI":"10.1002\/hipo.23275","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T12:43:17Z","timestamp":1604493797000},"page":"170-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effects of adolescent experience of food restriction and exercise on spatial learning and open field exploration of female rats"],"prefix":"10.1002","volume":"31","author":[{"given":"Tara G.","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Center for Neural Science New York University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5063-1156","authenticated-orcid":false,"given":"Andr\u00e9 A.","family":"Fenton","sequence":"additional","affiliation":[{"name":"Center for Neural Science New York University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4010-9425","authenticated-orcid":false,"given":"Chiye","family":"Aoki","sequence":"additional","affiliation":[{"name":"Center for Neural Science New York University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(02)00295-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300528"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.01.019"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21528"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.01.011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.03.011"},{"key":"e_1_2_7_8_1","first-page":"627","article-title":"Anxiolytic and antidepressant\u2010like activities of the novel and potent non\u2010imidazole histamine H3 receptor antagonist ST\u20101283","volume":"8","author":"Bahi A.","year":"2014","journal-title":"Drug Design, Development and Therapy"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.116.5.884"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/es903183r"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(199401)15:1<21::AID-EAT2260150104>3.0.CO;2-K"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904284106"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.04.017"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199901)45:1<8::AID-ART4>3.0.CO;2-V"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22013"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1102-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(18)30227-X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-016-1341-7"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.22034"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv087"},{"key":"e_1_2_7_21_1","article-title":"Activity\u2010based anorexia has differential effects on apical dendritic branching in dorsal and ventral hippocampal CA1","volume":"219","author":"Chowdhury T. 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