{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:10:10Z","timestamp":1747149010222,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:00:00Z","timestamp":1614384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000155","name":"Social Sciences and Humanities Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A prevailing view in cognitive neuroscience suggests that different forms of learning are mediated by dissociable memory systems, with a mesolimbic (i.e., midbrain and basal ganglia) system supporting incremental trial\u2010and\u2010error reinforcement learning and a hippocampal\u2010based system supporting episodic memory. Yet, growing evidence suggests that the hippocampus may also be important for trial\u2010and\u2010error learning, particularly value or reward\u2010based learning. In the present report, we use a lesion\u2010based neuropsychological approach to clarify hippocampal contributions to such learning. Six amnesic patients with medial temporal lobe damage and a group of healthy controls were administered a simple value\u2010based learning task involving probabilistic trial\u2010and\u2010error acquisition of stimulus\u2013response\u2010outcome (reward or none) contingencies modeled after Li et al. (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.zotero.org\/google-docs\/?bksSFQ\">Proceedings of the National Academy of Sciences<\/jats:ext-link>\n<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.zotero.org\/google-docs\/?bksSFQ\">,<\/jats:ext-link> 2011, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.zotero.org\/google-docs\/?bksSFQ\">108<\/jats:ext-link>\n<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.zotero.org\/google-docs\/?bksSFQ\">(1), 55\u201360<\/jats:ext-link>). As predicted, patients were significantly impaired on the task, demonstrating reduced learning of the contingencies. Our results provide further supportive evidence that the hippocampus' role in cognition extends beyond episodic memory tasks and call for further refinement of theoretical models of hippocampal functioning.<\/jats:p>","DOI":"10.1002\/hipo.23317","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T12:15:33Z","timestamp":1614428133000},"page":"461-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Probabilistic value learning in medial temporal lobe amnesia"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8082-3522","authenticated-orcid":false,"given":"Daniela J.","family":"Palombo","sequence":"first","affiliation":[{"name":"Department of Psychology University of British Columbia  Vancouver British Columbia Canada"},{"name":"VA Boston Healthcare System  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie M.","family":"Patt","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System  Boston Massachusetts USA"},{"name":"Department of Psychiatry Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee","family":"Hunsberger","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mieke","family":"Verfaellie","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System  Boston Massachusetts USA"},{"name":"Department of Psychiatry Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.03.036"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08998-1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.6.3072"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.10.080"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.03.042"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-13-04915.2001"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5217-12.2013"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/670067"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)90288-7"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.2140\/camcos.2010.5.65"},{"key":"e_1_2_5_12_1","unstructured":"Grinsted A. 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