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Functional MRI studies have demonstrated hippocampal hyperactivation in older adults compared to young, with greater task\u2010related activation associated with worse pattern separation performance. The current study was designed to determine whether pattern separation was sensitive to differences in task\u2010free hippocampal cerebral blood flow (CBF) in 130 functionally intact older adults. Given prior evidence that apolipoprotein E e4 (<jats:italic>APOE<\/jats:italic> e4) status moderates the relationship between CBF and episodic memory, we predicted a stronger negative relationship between hippocampal CBF and pattern separation in <jats:italic>APOE<\/jats:italic> e4 carriers. An interaction between <jats:italic>APOE<\/jats:italic> group and right hippocampal CBF was present, such that greater right hippocampal CBF was related to better lure discrimination in noncarriers, whereas the effect reversed directionality in e4 carriers. 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