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The primary aim of this investigation was to test if this pattern reported for imagined events would be found when repeatedly recollecting autobiographical memories. Twenty\u2010four participants retrieved 12 pre\u2010selected autobiographical memories four times while undergoing an fMRI scan. We used a region of interest approach to investigate how the anterior and posterior hippocampus as well as cortical regions critical for memory retrieval\u2014the vmPFC and the posterior cingulate cortex (PCC)\u2014are affected by repeated retrievals. This analysis revealed an effect in the bilateral anterior hippocampi and vmPFC, but not the posterior hippocampus nor the PCC, with activity decreasing in these regions as a function of repeated retrievals. A multivariate analytic approach (Partial Least Squares) was used to assess whole\u2010brain patterns of neural activity associated with repeated retrievals. This analysis revealed one pattern of neural activity associated with the initial retrieval of a memory (e.g., inferior frontal and temporal lobe regions) and a separate pattern of activity associated with later retrievals that was distributed primarily across the lateral parietal cortices. These findings suggest that the anterior hippocampus and the vmPFC support the episodic construction of an autobiographical memory the first time it is retrieved and that alternate nonconstructive processes support its subsequent retrieval shortly thereafter.<\/jats:p>","DOI":"10.1002\/hipo.23330","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T15:39:04Z","timestamp":1617982744000},"page":"869-880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Reduced anterior hippocampal and ventromedial prefrontal activity when repeatedly retrieving autobiographical memories"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1182-0085","authenticated-orcid":false,"given":"Lauri","family":"Gurguryan","sequence":"first","affiliation":[{"name":"Department of Psychology McGill University  Montreal Quebec 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