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Cortical activation was assessed by comparing power spectra of local field potentials (LFPs) during activated states of rapid\u2010eye\u2010movement sleep (REM) or walk (WLK), with those during non\u2010activated states of slow\u2010wave sleep (SWS) or awake\u2010immobility (IMM). Activation\u2010induced suppression of delta (1\u20134\u00a0Hz) and beta (13\u201330\u2009Hz) power in the hippocampus, and delta power in frontal cortex, were reduced in KO and KD mice compared to WT mice. Mean theta frequency was higher in KD than KO mice during WLK and REM, but not different between WT and KO mice. Peak theta (4\u201312\u2009Hz) and integrated gamma (30\u2013150\u2009Hz) power were not significantly different among mouse groups. However, theta\u2010peak\u2010frequency selected gamma2 (62\u2013100\u2009Hz) power was lower in KO than WT or KD mice during WLK, and theta\u2010peak\u2010frequency selected theta power during REM decreased faster with high theta frequency in KO than WT\/ KD mice. Theta power increase during REM compared to WLK was lower in KO and KD mice compared to WT mice. Theta\u2013gamma cross\u2010frequency coherence, a measure of synchronization of gamma with theta phase, was not different among mouse groups. However, during REM, SWS, and IMM, delta\u2010gamma coherence was significantly higher and proximal\u2013distal delta coherence in CA1 was lower in KO than WT\/KD mice. We conclude that a deficiency in basal forebrain acetylcholine release not only enhances slow waves and suppresses theta\u2010associated gamma waves during activation, but also increases delta\u2010gamma cross\u2010frequency coherence during nonactivated states, with a possible effect of disrupting cognitive processing during any brain state.<\/jats:p>","DOI":"10.1002\/hipo.23387","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T16:43:01Z","timestamp":1631637781000},"page":"1233-1253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Aberrant slow waves in the hippocampus during activation in mice with low cholinergic tone"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8887-4869","authenticated-orcid":false,"given":"L. 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