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We recorded single\u2010neuron and local field potentials from the human hippocampus in epilepsy patients implanted with depth electrodes. We detected theta\u2010frequency bouts of oscillatory activity while patients performed a visual recognition memory task. Theta appeared in bouts of 3.16\u2009cycles, with sawtooth\u2010shaped oscillations that had a prolonged downswing period. Outside the seizure onset zone, the average frequency of theta bouts was higher in the RH compared to the LH (6.0 vs. 5.3\u2009Hz). LH theta bouts had lower amplitudes and a higher prevalence compared to the RH (26% vs. 21% of total time). Additionally, the RH contained a population of thin spiking visually tuned neurons that were not present in the LH. These data show that human theta appears in short oscillatory bouts whose properties vary between hemispheres, thereby revealing neurophysiological properties of the hippocampus that differ between the hemispheres.<\/jats:p>","DOI":"10.1002\/hipo.23412","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T17:59:20Z","timestamp":1646157560000},"page":"335-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Properties and hemispheric differences of theta oscillations in the human hippocampus"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6260-856X","authenticated-orcid":false,"given":"Cooper","family":"Penner","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4942-3269","authenticated-orcid":false,"given":"Juri","family":"Minxha","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Cedars\u2010Sinai Medical Center  Los Angeles California USA"},{"name":"Center for Theoretical Neuroscience, College of Physicians and Surgeons Columbia University  New York New York USA"},{"name":"Department of Neurology Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nand","family":"Chandravadia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam N.","family":"Mamelak","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9207-7069","authenticated-orcid":false,"given":"Ueli","family":"Rutishauser","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Cedars\u2010Sinai Medical Center  Los Angeles California USA"},{"name":"Department of Neurology Cedars\u2010Sinai Medical Center  Los Angeles California USA"},{"name":"Division of Biology and Biological Engineering California Institute of Technology  Pasadena California USA"},{"name":"Department of Biomedical Sciences, Center for Neural Science and Medicine Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.10.062"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.15541"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5319-09.2010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00586-X"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2016.12.008"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00273.2019"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4352-03.2004"},{"key":"e_1_2_5_9_1","unstructured":"Corsi P. M.(1973).Human memory and the medial temporal region of the brain Dissertation Abstracts International (34 2\u2010B 891)."},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902330104"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.09.017"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.5.1249"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15670-6"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.03.077"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(78)90212-2"},{"key":"e_1_2_5_16_1","volume-title":"Medicine, mind, and the double brain: A study in nineteenth\u2010century thought","author":"Harrington A.","year":"1989"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0304"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2016.06.010"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(78)90043-X"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23188"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.14.9.851"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(01)00278-1"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.01.032"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.05.019"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(75)90195-8"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17010"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20937"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22751"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04847-9"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba3313"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0108-2"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1380-19.2019"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08860"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807461105"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90376-7"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.08.024"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22124"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.04.003"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.08.052"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5102-14.2015"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.23412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hipo.23412","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/hipo.23412","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.23412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T19:23:57Z","timestamp":1692991437000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.23412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/hipo.23412"],"URL":"https:\/\/doi.org\/10.1002\/hipo.23412","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"2021-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}