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Recordings were made during walk and awake\u2010immobility (IMM) in WT mice, and in mice with forebrain knockout (KO) of the vesicular acetylcholine transporter (VAChT) gene, or heterozygous knockdown of VAChT gene (KD). Scopolamine or CPP did not significantly alter walk theta frequency, which was higher in KD than WT\/KO mice. Scopolamine decreased theta power peak rise during walk in WT\/KD mice but not in KO mice, while CPP suppressed theta peak rise more in WT\/KO mice than KD mice. During IMM, scopolamine decreased gamma1 (\u03b31, 30\u201358\u2009Hz) power more in KD\/WT mice than KO mice, while delta (1\u20134\u00a0Hz) power and delta\u2010gamma cross\u2010frequency coherence (CFC) were increased in all mouse groups during IMM or walk. During walk, scopolamine increased delta and beta (13\u201330\u2009Hz) power and decreased gamma2 (\u03b32, 62\u2013100\u2009Hz) power and theta\u2010\u03b32 CFC more in WT\/KD than KO mice. Theta\u2010\u03b32, but not theta\u2010\u03b31, CFC increased with theta\u2010peak\u2010frequency in WT\/KD mice, and was suppressed by scopolamine at high theta (8\u201310\u00a0Hz) frequency; theta\u2010\u03b32 CFC in KO mice was not significantly altered by scopolamine. CPP decreased beta and gamma power more in KD\/KO mice compared to WT mice, while delta power and delta\u2010gamma CFC were increased in all mouse groups. ACh deficiency exacerbates the attenuation of beta and gamma power by CPP. We conclude that both muscarinic and NMDA transmission contribute toward hippocampal theta, beta, and gamma power, and a decrease in gamma power or theta\u2010gamma CFC may be associated with loss of arousal and cognitive functions.<\/jats:p>","DOI":"10.1002\/hipo.23462","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T09:20:54Z","timestamp":1660382454000},"page":"731-751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Muscarinic and N\u2010methyl\u2010D\u2010aspartate receptor blockade reveal differences in hippocampal local field potentials in mice with low cholinergic tone"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8887-4869","authenticated-orcid":false,"given":"L. 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