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Dentate spikes (DSs) are high\u2010amplitude, fast, positive local\u2010field potential events taking place in the DG during immobility and sleep, and they have been connected to memory consolidation in rodents. DSs are a result of signaling from the entorhinal cortex (EC) to the DG, and they suppress firing of pyramidal cells in the CA3 and CA1. To study the effects of DSs to signaling in the hippocampal tri\u2010synaptic loop, we electrically stimulated the afferent fibers of the DG, CA3, and CA1 in adult male Sprague\u2013Dawley rats at different delays from DSs. Responses to stimulation were increased in the EC\u2010DG synapse during DSs, and the effect was amplified after theta\u2010burst stimulation. We concluded that DSs strengthen the excitatory signal from the EC to the DG, which is reinforced by synapse potentiation and increased excitability of granule cells after theta\u2010burst stimulation. This signal boosting may function in enhancing plastic changes in the DG\u2010CA3 synapse. As responses in the CA3 and CA1 remained unaffected by the DS, the DS\u2010contingent silencing of pyramidal cells seems to be a result of a decrease in excitatory input rather than a decrease in the excitability of the pyramidal cells themselves. In addition, we found that the DSs occur asynchronously in the left and right hippocampi, giving novel evidence of lateralization of the rodent hippocampus.<\/jats:p>","DOI":"10.1002\/hipo.23470","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T12:25:27Z","timestamp":1663331127000},"page":"808-817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hippocampal responses to electrical stimulation of the major input pathways are modulated by dentate spikes"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7911-3280","authenticated-orcid":false,"given":"Suvi\u2010Maaria","family":"Lehtonen","sequence":"first","affiliation":[{"name":"Department of Psychology University of Jyvaskyla  Jyvaskyla Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomi","family":"Waselius","sequence":"additional","affiliation":[{"name":"Department 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