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Second, we examined cortical A\u03b2 associations with fornix microstructure. Seventeen early AD patients and 17 healthy\u2010matched controls were included. Constrained spherical deconvolution\u2010based tractography was used to segment the fornix and a control tract the central branch of the superior longitudinal fasciculus (CB\u2010SLF) previously implicated in working memory processes. Standard uptake value ratios (SUVR) of A\u03b2 were extracted from 45 cortical\/subcortical regions from the AAL atlas and subject to principal component analysis for data reduction. Patients exhibited (i) impairments in cognitive performance (ii) reductions in fornix fractional anisotropy (FA) and (iii) increases in a component that loaded highly on cortical A\u03b2. There were no group differences in CB\u2010SLF FA and in a component loading highly on subcortical A\u03b2. Partial correlation analysis in the patient group showed (i) positive associations between fornix FA and performance for all the visual object categories and (ii) a negative association between the cortical A\u03b2 component and performance for the object categories but not for the remaining classes of visual stimuli. A subsequent analysis showed a positive association between overall cognition (performance across distinct 1\u2010back task conditions) with fornix FA but no association with cortical A\u03b2 burden, in keeping with influential accounts on early onset AD. This indicates that the fornix degenerates early in AD and contributes to deficits in working memory processing of visual object categories; though it is also important to acknowledge the importance of prospective longitudinal studies with larger samples. Overall, the effect sizes of fornical degeneration on visual working memory appeared stronger than the ones related to amyloid burden.<\/jats:p>","DOI":"10.1002\/hipo.23493","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T07:10:14Z","timestamp":1672297814000},"page":"112-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Associations between cortical \u03b2\u2010amyloid burden, fornix microstructure and cognitive processing of faces, places, bodies and other visual objects in early Alzheimer's disease"],"prefix":"10.1002","volume":"33","author":[{"given":"Jos\u00e9","family":"Bourbon\u2010Teles","sequence":"first","affiliation":[{"name":"HEI\u2010Lab Lus\u00f3fona University  Lisbon Portugal"},{"name":"Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Institute for Nuclear Sciences Applied to Health (ICNAS) University of Coimbra  Coimbra Portugal"},{"name":"Faculty of Medicine University of Coimbra  Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edlia","family":"Jorge","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Institute for Nuclear Sciences Applied to Health (ICNAS) University of Coimbra  Coimbra Portugal"},{"name":"Faculty of Medicine University of Coimbra  Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1dia","family":"Can\u00e1rio","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Institute for Nuclear Sciences Applied to Health (ICNAS) University of Coimbra  Coimbra Portugal"},{"name":"Faculty of Medicine University of Coimbra  Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7184-185X","authenticated-orcid":false,"given":"Ricardo","family":"Martins","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Institute for Nuclear Sciences Applied to Health (ICNAS) University of Coimbra  Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Santana","sequence":"additional","affiliation":[{"name":"Department of Neurology Coimbra University Hospital  Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4364-6373","authenticated-orcid":false,"given":"Miguel","family":"Castelo\u2010Branco","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Institute for Nuclear Sciences Applied to Health (ICNAS) University of Coimbra  Coimbra Portugal"},{"name":"Faculty of Medicine University of Coimbra  Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00266"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2011.09.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0166-4328(05)80325-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.14609568.2010.07251.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_8_7_1","first-page":"69","volume-title":"Grupo de Estudos de Envelhecimento cerebral e Dem\u00eancias [study group on brain aging and dementia]. 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