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A novel spatial navigation task recently revealed that such \u201creplay\u201d sequences of place fields can also prospectively map onto imminent new paths to a goal that occupies a stable location during each session. It was hypothesized that such \u201cprospective replay\u201d sequences may play a <jats:italic>causal<\/jats:italic> role in goal\u2010directed navigation. In the present study, we query this putative causal role in finding only minimal effects of muscimol\u2010induced inactivation of the dorsal and intermediate hippocampus on the same spatial navigation task. The concentration of muscimol used demonstrably inhibited hippocampal cell firing in vivo and caused a severe deficit in a hippocampal\u2010dependent \u201cepisodic\u2010like\u201d spatial memory task in a watermaze. 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