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It can be divided into the medial entorhinal cortex (MEC) and the lateral entorhinal cortex (LEC), which are commonly theorized to be critical for spatial (context) and non\u2010spatial (content) inputs, respectively. Consistent with this theory, LEC neurons are found to carry little information about allocentric self\u2010location, even in cue\u2010rich environments, but they exhibit egocentric spatial information about external items in the environment. The superficial and deep layers of LEC are believed to mediate the input to and output from the hippocampus, respectively. As earlier studies mainly examined the spatial firing properties of superficial\u2010layer LEC neurons, here we characterized the deep\u2010layer LEC neurons and made direct comparisons with their superficial counterparts in single unit recordings from behaving rats. Because deep\u2010layer LEC cells received inputs from hippocampal regions, which have strong selectivity for self\u2010location, we hypothesized that deep\u2010layer LEC neurons would be more informative about allocentric position than superficial\u2010layer LEC neurons. We found that deep\u2010layer LEC cells showed only slightly more allocentric spatial information and higher spatial consistency than superficial\u2010layer LEC cells. Egocentric coding properties were comparable between these two subregions. In addition, LEC neurons demonstrated preferential firing at lower speeds, as well as at the boundary or corners of the environment. These results suggest that allocentric spatial outputs from the hippocampus are transformed in deep\u2010layer LEC into the egocentric coding dimensions of LEC, rather than maintaining the allocentric spatial tuning of the CA1 place fields.<\/jats:p>","DOI":"10.1002\/hipo.23528","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T20:06:50Z","timestamp":1679774810000},"page":"448-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Superficial\u2010layer versus deep\u2010layer lateral entorhinal cortex: Coding of allocentric space, egocentric space, speed, boundaries, and corners"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2917-877X","authenticated-orcid":false,"given":"Cheng","family":"Wang","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology Chinese Academy of Sciences  Shenzhen 518055 China"},{"name":"Shenzhen\u2010Hong Kong Institute of Brain Science\u2010Shenzhen Fundamental Research Institutions  Shenzhen 518055 China"},{"name":"Zanvyl Krieger Mind\/Brain Institute Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heekyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Zanvyl Krieger Mind\/Brain Institute Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geeta","family":"Rao","sequence":"additional","affiliation":[{"name":"Zanvyl Krieger Mind\/Brain Institute Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7122-6953","authenticated-orcid":false,"given":"Yoganarasimha","family":"Doreswamy","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy University of Texas Medical School at Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Savelli","sequence":"additional","affiliation":[{"name":"Zanvyl Krieger Mind\/Brain Institute Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1796-2930","authenticated-orcid":false,"given":"James J.","family":"Knierim","sequence":"additional","affiliation":[{"name":"Zanvyl Krieger Mind\/Brain Institute Johns Hopkins University  Baltimore Maryland USA"},{"name":"Solomon H. 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