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Unlike entorhinal cortical inputs, the Schaffer collateral inputs to CA2 do not support activity\u2010dependent long\u2010term potentiation (LTP), which serves as the basis for long\u2010term memories. This LTP\u2010resistant zone also expresses genes that restrict plasticity. With the aim of exploring social interaction and sociability in rats that were subjected to juvenile stress, we addressed questions about how the neural circuitry is altered and its effects on social behavior. Although there was induction of LTP in both Schaffer collateral and entorhinal cortical pathways in juvenile\u2010stressed rats, LTP declined in both pathways after 2\u20133\u2009h. Moreover, exogenous bath application of substance P, a neuropeptide that resulted in slow onset long\u2010lasting potentiation in control animals while it failed to induce LTP in juvenile\u2010stressed rats. Our study reveals that juvenile\u2010stressed rats show behavioral and cellular abnormalities with a long\u2010lasting impact in adulthood.<\/jats:p>","DOI":"10.1002\/hipo.23531","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T19:49:56Z","timestamp":1679773796000},"page":"745-758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Alteration of hippocampal <scp>CA2<\/scp> plasticity and social memory in adult rats impacted by juvenile stress"],"prefix":"10.1002","volume":"33","author":[{"given":"Radha","family":"Raghuraman","sequence":"first","affiliation":[{"name":"Department of Physiology National University of Singapore  Singapore 117593 Singapore"},{"name":"Life Sciences Institute Neurobiology Programme Centre for Life Sciences, National University of Singapore  Singapore 117456 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1754-711X","authenticated-orcid":false,"given":"Sheeja","family":"Navakkode","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore 308232 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5761-8982","authenticated-orcid":false,"given":"Sreedharan","family":"Sajikumar","sequence":"additional","affiliation":[{"name":"Department of Physiology National University of Singapore  Singapore 117593 Singapore"},{"name":"Life Sciences Institute Neurobiology Programme Centre for Life Sciences, National University of Singapore  Singapore 117456 Singapore"},{"name":"Healthy Longevity Translational Research Programme Yong Loo Lin School of Medicine, National University of Singapore  Singapore 117456 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10300"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-005-0624-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.02.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145704004808"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-3223(98)00138-3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2885-20.2021"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-018-5187-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096\u20109861(19970721)384:1<41::aid\u2010cne3>3.0.co;2\u2010l"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2018.07.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137221"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0245-16.2016"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2771-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.04.013"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1711267114"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5488-08.2009"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23476"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400794101"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-006-0335-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2011.04.015"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.09.047"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902290204"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13028"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2019.101993"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2021.07.001"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890009001125"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3791\/2473"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17144"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3614"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.036"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23478"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.11.026"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0149-7634(05)80206-4"},{"issue":"11","key":"e_1_2_8_34_1","first-page":"12628","article-title":"Neurobiology of substance P and the NK1 receptor","volume":"63","author":"Mantyh P. 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