{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:05:06Z","timestamp":1779242706010,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Traumatic experiences are closely associated with some psychiatric conditions such as post\u2010traumatic stress disorder. Deconditioning\u2010update promotes robust and long\u2010lasting attenuation of aversive memories. The deconditioning protocol consists of applying weak\/neutral footshocks during reactivations, so that the original tone\u2010shock association is replaced by an innocuous stimulus that does not produce significant fear response. Here, we present the molecular bases that can support this mechanism. To this end, we used pharmacological tools to inhibit the activity of ionotropic glutamate receptors (NMDA\u2010GluN2B and CP\u2010AMPA), the activity of proteases (calpains), and the receptors that control intracellular calcium storage (IP3 receptors), as well as the endocannabinoid system (CB1). Our results indicate that blocking these molecular targets prevents fear memory update by deconditioning. Therefore, this study uncovered the molecular substrate of deconditioning\u2010update strategy, and, broadly, shed new light on the traumatic memory destabilization mechanisms that might be used to break the boundaries regarding reconsolidation\u2010based approaches to deal with maladaptive memories.<\/jats:p>","DOI":"10.1002\/hipo.23579","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T10:54:26Z","timestamp":1696503266000},"page":"1267-1276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Molecular mechanisms underpinning deconditioning\u2010update in fear memory"],"prefix":"10.1002","volume":"33","author":[{"given":"Bruno","family":"Popik","sequence":"first","affiliation":[{"name":"Neurobiology of Memory Lab, Biophysics Department Biosciences Institute, Federal University of Rio Grande do Sul  Porto Alegre 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