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Despite the extensive research of the classic subfields of the hippocampus, the fasciola cinerea (FC)\u2014a medially located structure within the hippocampal formation\u2014has remained largely unexplored. In the present study, we performed a morpho\u2010functional characterization of principal neurons in the mouse FC. Using in vivo juxtacellular recording of single neurons, we found that FC neurons are distinct from neighboring CA1 pyramidal cells, both morphologically and electrophysiologically. Specifically, FC neurons displayed non\u2010pyramidal morphology and granule cell\u2010like apical dendrites. Compared to neighboring CA1 pyramidal neurons, FC neurons exhibited more regular in vivo firing patterns and a lower tendency to fire spikes at short interspike intervals. Furthermore, tracing experiments revealed that the FC receives inputs from the lateral but not the medial entorhinal cortex and CA3, and it provides a major intra\u2010hippocampal projection to the septal CA2 and sparser inputs to the distal CA1. Overall, our results indicate that the FC is a morphologically and electrophysiologically distinct subfield of the hippocampal formation; given the established role of CA2 in social memory and seizure initiation, the unique efferent intra\u2010hippocampal connectivity of the FC points to possible roles in social cognition and temporal lobe epilepsy.<\/jats:p>","DOI":"10.1002\/hipo.23623","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T10:55:45Z","timestamp":1722941745000},"page":"528-539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anatomical and electrophysiological analysis of the fasciola cinerea of the mouse hippocampus"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4032-3723","authenticated-orcid":false,"given":"Ioannis S.","family":"Zouridis","sequence":"first","affiliation":[{"name":"Institute of Neurobiology, Eberhard Karls 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