{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:43:18Z","timestamp":1783626198425,"version":"3.55.0"},"reference-count":93,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G03000117"],"award-info":[{"award-number":["G03000117"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G1002276"],"award-info":[{"award-number":["G1002276"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite bilateral hippocampal damage dating to the perinatal or early childhood period and severely impaired episodic memory, patients with developmental amnesia continue to exhibit well\u2010developed semantic memory across the developmental trajectory. Detailed information on the extent and focality of brain damage in these patients is needed to hypothesize about the neural substrate that supports their remarkable capacity for encoding and retrieval of semantic memory. In particular, we need to assess whether the residual hippocampal tissue is involved in this preservation, or whether the surrounding cortical areas reorganize to rescue aspects of these critical cognitive memory processes after early injury. We used voxel\u2010based morphometry (VBM) analysis, automatic (FreeSurfer) and manual segmentation to characterize structural changes in the brain of an exceptionally large cohort of 23 patients with developmental amnesia in comparison with 32 control subjects. Both the VBM and the FreeSurfer analyses revealed severe structural alterations in the hippocampus and thalamus of patients with developmental amnesia. Milder damage was found in the amygdala, caudate, and parahippocampal gyrus. Manual segmentation demonstrated differences in the degree of atrophy of the hippocampal subregions in patients. The level of atrophy in CA\u2010DG subregions and subicular complex was more than 40%, while the atrophy of the uncus was moderate (\u221224%). Anatomo\u2010functional correlations were observed between the volumes of residual hippocampal subregions in patients and selective aspects of their cognitive performance, viz, intelligence, working memory, and verbal and visuospatial recall. Our findings suggest that in patients with developmental amnesia, cognitive processing is compromised as a function of the extent of atrophy in hippocampal subregions. More severe hippocampal damage may be more likely to promote structural and\/or functional reorganization in areas connected to the hippocampus. In this hypothesis, different levels of hippocampal function may be rescued following this variable reorganization. Our findings document not only the extent, but also the limits of circuit reorganization occurring in the young brain after early bilateral hippocampal damage.<\/jats:p>","DOI":"10.1002\/hipo.23638","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T13:35:04Z","timestamp":1726234504000},"page":"645-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anatomo\u2010functional changes in neural substrates of cognitive memory in developmental amnesia: Insights from automated and manual <scp>Magnetic Resonance Imaging<\/scp> examinations"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2043-3711","authenticated-orcid":false,"given":"Lo\u00efc J.","family":"Chareyron","sequence":"first","affiliation":[{"name":"Cognitive Neuroscience and Neuropsychiatry Section, Developmental Neurosciences Department University College London Great Ormond Street Institute of Child Health  London UK"},{"name":"Laboratory of Brain and Cognitive Development, Institute of Psychology University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. K. Kling","family":"Chong","sequence":"additional","affiliation":[{"name":"Developmental Imaging and Biophysics, Developmental Neurosciences Department University College London Great Ormond Street Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Banks","sequence":"additional","affiliation":[{"name":"Developmental Imaging and Biophysics, Developmental Neurosciences Department University College London Great Ormond Street Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Burgess","sequence":"additional","affiliation":[{"name":"Institute of Cognitive Neuroscience University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Saunders","sequence":"additional","affiliation":[{"name":"Laboratory of Neuropsychology, National Institute of Mental Health National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faraneh","family":"Vargha\u2010Khadem","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience and Neuropsychiatry Section, Developmental Neurosciences Department University College London Great Ormond Street Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.01.038"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1063(2000)10:4<466::AID-HIPO13>3.0.CO;2-Y"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-018-9835-y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23452"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2014.04.013"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902240302"},{"key":"e_1_2_9_8_1","first-page":"37","volume-title":"The hippocampus book","author":"Amaral D. G.","year":"2007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2009.01.006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2010.03.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(89)90092-4"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.12.009"},{"key":"e_1_2_9_13_1","volume-title":"Doors and people: A test of visual and verbal recall and recognition","author":"Baddeley A. D.","year":"1994"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5412-05.2006"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.137"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1063(2001)11:1<61::AID-HIPO1021>3.0.CO;2-Z"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20057"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(1999)9:5<562::AID-HIPO10>3.0.CO;2-X"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp289"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23401"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01384"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1355617700611116"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604288113"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-017-1441-z"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2011.03.008"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/2398212817701448"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07309-z"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-010-0674-9"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.148205"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23416"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20940"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23786"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2016.09.016"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.07.026"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X00035391"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2021.107788"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.04.040"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.79.2.0256"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200033797"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0396"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22170"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.3.499"},{"key":"e_1_2_9_45_1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1109\/EMBC.2012.6345960","volume-title":"2012 Annual international conference of the IEEE Engineering in Medicine and Biology Society","author":"Gao J.","year":"2012"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0801-15.2015"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3086-07.2008"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-018-1802-2"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199811000-00065"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.04.042"},{"issue":"4","key":"e_1_2_9_51_1","first-page":"659","article-title":"MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices","volume":"19","author":"Insausti R.","year":"1998","journal-title":"AJNR. American Journal of Neuroradiology"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1233825100"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1740-23.2024"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23010"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858412470976"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-41874-8_24"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22056"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.02.007"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1820"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20730"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0655-14.2014"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000086465.41263.06"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.04.001"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00146-6"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(92)90001-4"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1997.0132"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-019-0213-6"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2013.11.001"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-16-06568.1998"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000186516.85702.61"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1511904112"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz383"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.10.003"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181e9f1ba"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-16-05233.1996"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00196"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.01.040"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.06.023"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24017"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90001-5"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.20.1.11"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0710-08.2008"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-7496"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.11.019"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14445"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410109"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5324.376"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1233756100"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(99)00089-5"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23567"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2010.00012"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.015"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2015.09.002"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-10-02950.1986"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.23638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T09:57:55Z","timestamp":1729245475000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.23638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,13]]},"references-count":93,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/hipo.23638"],"URL":"https:\/\/doi.org\/10.1002\/hipo.23638","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,13]]},"assertion":[{"value":"2024-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}