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Both pre\u2010 and post\u2010synaptic activation of 5\u2010HT1a receptor, respectively, in the rat median raphe nucleus (MnRN) and hippocampus, lead to adaptation to acute inescapable stressors such as restraint and forced swim. 5\u2010HT7 receptor (5HT7r), a stimulatory G\u2010protein coupled receptor, has also been investigated as a possible candidate for mediating stress response. In the MnRN, activation of 5\u2010HT7r has antidepressant effects, while in the hippocampus, 5HT7r mRNA expression is increased after exposure to restraint stress, but the functional significance of these receptors remains to be determined. Therefore, the aim of this study was to investigate whether blockade of hippocampal 5HT7r would prevent and\/or attenuate the behavioral effects of stress. Male adult Wistar rats with bilateral cannulas aimed at the dorsal hippocampus were restrained for 2\u2009h and tested in the elevated plus maze (EPM) 24\u2009h later. SB 258741 (3\u2009nmoles\/0.5\u2009\u03bcL\/side; selective 5HT7r antagonist) was administered bilateraly into the hippocampus according to the experimental protocol: immediately before or after stress, or 24\u2009h after it (immediately before the test). In a second experiment, rats were exposed to 15\u2009min. of forced swim, and tested 24\u2009h later. Intra\u2010hippocampal treatment was performed as described for the restraint stress protocol. We found that blockade of hippocampal 5\u2010HT7r immediately after, but not before, the exposure to restraint or forced swim attenuated stress\u2010induced behavioral changes. Similar results were obtained when SB was administered before the test in previously stressed rats. Our data suggest that activation of hippocampal 5\u2010HT7r is crucial for the consolidation and retrieval of aversive stimulus\u2010related memories, such as those caused by a stressful experience, probably through mechanisms involving stress\u2010induced changes in 5\u2010HT7r expression.<\/jats:p>","DOI":"10.1002\/hipo.23663","type":"journal-article","created":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T15:09:17Z","timestamp":1733584157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Behavioral Consequences of Hippocampal 5\u2010<scp>HT7<\/scp> Receptors Blockade in Stressed Rats"],"prefix":"10.1002","volume":"35","author":[{"given":"Adriana Colsera","family":"Pereira","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Neurobiologia Do Estresse e da Depress\u00e3o, Faculdade de Filosofia, Ci\u00eancias e Letras de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo  Ribeir\u00e3o Preto SP 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