{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:20:08Z","timestamp":1791152408226,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":5034,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Simultaneously recorded pairs (from a single electrode) of cells in the medial septum (MS) vertical limb of the diagonal band of Broca (vDBB) were studied during the simultaneous occurrence of field activity in the hippocampal formation of urethane\u2010anesthetized rats and following the systemic administration of atropine sulphate (ATSO<jats:sub>4<\/jats:sub>). The 2 types of field activities recorded were cholinergically mediated type 2 theta (\u03b8) and large\u2010amplitude irregular activity (LIA). The study had 3 objectives: (1) to determine if cells in close proximity in the MS\/vDBB had a high probability of having similar discharge properties; (2) to determine the possible functional relationships occurring between pairs of MS\/vDBB cells using standard cross correlational analyses; and (3) to determine the effects of ATSO<jats:sub>4<\/jats:sub> on both the discharge properties of MS\/vDBB cells and the interactions between these cells. Of the 143 cells recorded, 133 (93%) were \u03b8\u2010related and classified as \u03b8\u2010on or \u03b8\u2010off cells. \u03b8\u2010on cells had a significant increase in mean discharge rate during \u03b8 compared to their mean discharge rate during LIA and\/or had a linear increase in discharge rate in relation to increases in \u03b8 frequency. \u03b8\u2010off cells had a significant increase in mean discharge rate during LIA compared to their mean discharge rate during \u03b8 and\/or had a linear decrease in discharge rate in relation to increases in \u03b8 frequency. The remaining 10 (7%) cells were classified as nonrelated to \u03b8. A probability analysis carried out on each of the separate criteria for classification revealed that several of these could predict whether or not cells were in close proximity of one another. Cells occurred in close proximity according to whether they had higher discharge rate during \u03b8 or LIA and according to whether or not they varied their discharge rates as \u03b8 frequency varied (linear\u2010nonlinear). Cell discharge patterns of rhythmicity (phasic), or nonrhythmicity (tonic) on the other hand, were not good predictors of whether cells were in close proximity since there was an equal probability of a phasic cell being paired with either a phasic or a tonic cell. The presence of a phasic discharge pattern was, however, the main determinant of whether a correlation occurred between cell pairs. Cross correlations of the cell pair spike trains revealed that 50% of the 36 phasic\u2010phasic cell pairs were correlated during both \u03b8 and LIA field activities. The characteristics of the cross correlation functions of these cell pairs (strong symmetrical correlations with sharp primary peaks or troughs occurring around the origin) suggested that they received shared excitatory and inhibitory inputs. The remaining 50% of the phasic\u2010phasic pairs were cross correlated during \u03b8 only. Seventeen (68%) of 25 cell pairs consisting of one phasic and one tonic cell were cross correlated during \u03b8 only, and the 12 tonic\u2010tonic cell pairs were not cross correlated during \u03b8 or LIA. The systemic administration of ATSO<jats:sub>4<\/jats:sub> abolished all 6 field activity in the hippocampal formation as analyzed visually and by fourier analysis. Twenty\u2010three out of 32 (71.9%) phasic cells continued to discharge in a phasic pattern, while the remaining 9 cells (28.1%) became irregular following the administration of ATSO<jats:sup>4<\/jats:sup> The effects of ATSO<jats:sub>4<\/jats:sub> on the interaction between cell pairs appeared to be dependent on two factors: (1) the nature of their interactions in the pre\u2010drug condition, during \u03b8 and LIA; and (2) whether or not the cell(s) were phasic during ATSO<jats:sub>4<\/jats:sub>, Cell pairs that were cross correlated during both \u03b8 and LIA were always cross correlated during ATSO<jats:sub>4<\/jats:sub>, regardless of what effect ATSO<jats:sub>4<\/jats:sub> had on each cell. Cell pairs that were cross correlated only during \u03b8 were cross correlated during ATSO<jats:sub>4<\/jats:sub> only if at least 1 of the cells in the pair remained phasic. These data suggest that there is a critical subpopulation of phasic \u03b8\u2010on and \u03b8off MSivDBB cells (approximately 50%) that share excitatory and inhibitory inputs, possibly from ascending synchronizing and desynchronizing pathways. The exact nature of the control that the output of these and other MS\/vDBB cells exerts on hippocampal field and cellular activity, remains to be determined.<\/jats:p>","DOI":"10.1002\/hipo.450010104","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:58:03Z","timestamp":1104541083000},"page":"15-30","source":"Crossref","is-referenced-by-count":36,"title":["Medial septal cell interactions in relation to hippocampal field activity and the effects of atropine"],"prefix":"10.1002","volume":"1","author":[{"given":"Luis V.","family":"Colom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian H.","family":"Bland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90162-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90040-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90298-4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90745-5"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(86)90019-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90963-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91171-7"},{"key":"e_1_2_1_9_1","first-page":"120","article-title":"Theta\u2010on, theta\u2010off cells in the medial septum and vertical limb of the diagonal band","volume":"31","author":"Bland B. 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