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Oriens lacunosum\u2010moleculare (OLM) interneurons, identified by the\n                    <jats:italic>Chrna2<\/jats:italic>\n                    gene, are known to regulate memory processes differently along this axis. OLM\u02512 cells bidirectionally modulate risk\u2010taking behavior, while ventral hippocampal medial prefrontal cortex (mPFC)\u2010projecting neurons regulate approach and avoidance behaviors. Using rabies virus\u2010mediated monosynaptic retrograde tracing, we show that OLM\u02512 cells receive differential innervation across the dorsal, intermediate, and ventral hippocampus. We find that CA1 and CA3 inputs differ between hippocampal poles, suggesting that OLM\u02512 cells may have distinct feedback and feed\u2010forward inhibitory roles in the hippocampal microcircuit. Intermediate OLM\u02512 cells uniquely receive substantial input from the subiculum and dorsal\/medial raphe nuclei, as well as widespread CA2 inputs potentially linked to social memory. The medial septum and diagonal band of Broca provide cholinergic, GABAergic, and glutamatergic inputs across the axis, likely influencing disinhibition and oscillatory activity during various behavioral states. Excitatory input to intermediate\u2010ventral OLM\u02512 cells partly arises from CA1 projection neurons targeting the mPFC. This suggests a gate\u2010switching function that favors CA3 input to projection neurons by two different mechanisms related to feedback and feed\u2010forward inhibition. In conclusion, OLM\u02512 cells exhibit distinct presynaptic input profiles along the dorsoventral axis, with major differences in the proportions of intrahippocampal inputs, highlighting their diverse roles in hippocampal microcircuits.\n                  <\/jats:p>","DOI":"10.1002\/hipo.70026","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T12:04:47Z","timestamp":1754309087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Differentiated Presynaptic Input to\n                    <scp>OLM\u02512<\/scp>\n                    Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5698-3712","authenticated-orcid":false,"given":"Angelica","family":"Thulin","sequence":"first","affiliation":[{"name":"Department of Immunology, Genetics and Pathology Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5158-1912","authenticated-orcid":false,"given":"Katharina","family":"Henriksson","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Brain Institute, Federal University of Rio Grande do Norte  Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6418-5460","authenticated-orcid":false,"given":"Klas","family":"Kullander","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.77364"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa5694"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23888"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0241-y"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan3846"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan3846"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1995.tb00638.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.04.014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv098"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP271946"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-018-2882-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1413-04.2004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115714"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.615337"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22488"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0409-15.2015"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108694"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.05.002"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2306382121"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.04.013"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3538"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa3245"},{"key":"e_1_2_7_25_1","volume-title":"Memory, Amnesia, and the Hippocampal System","author":"Cohen N. 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