{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:42:20Z","timestamp":1783626140830,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["PGSD3\u2010559227\u20102021"],"award-info":[{"award-number":["PGSD3\u2010559227\u20102021"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102018\u201006399"],"award-info":[{"award-number":["RGPIN\u20102018\u201006399"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT\u2010162274"],"award-info":[{"award-number":["PJT\u2010162274"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Visual exploration\u2014where the eyes move and when\u2014is guided by prior experiences. Memory\u2010guided viewing behavior is altered in healthy aging and is further disrupted in amnestic mild cognitive impairment (aMCI), a condition in which there is accelerated structural and functional decline of the hippocampus and associated medial temporal lobe structures (HC\/MTL). Computational modeling has demonstrated the potential for rapid information flow from the HC\/MTL to regions responsible for the cognitive control of eye movements, such that visual exploration behavior could be impacted in the moment and on an ongoing fashion. It was predicted here, then, that older adults and individuals with aMCI would show changes in naturalistic viewing compared to younger adults, even in the absence of any memory task. Multivariate analyses revealed that viewing for younger adults was characterized by larger saccade amplitudes and a larger area of exploration; the opposite pattern was reliably expressed by individuals with aMCI. Viewing patterns of healthy older adults were associated with shorter gaze durations. The entropy of viewing in older adults was associated with overall cognitive status, as determined by the Montreal Cognitive Assessment, highlighting the top\u2010down influence of cognitive function on active vision. Lower scores on the memory subtest were reliably associated with a pattern of viewing characterized by fewer fixations (with longer durations), saccades, regions explored, smaller area of exploration, and lower entropy, mimicking some of the viewing features of the aMCI group and suggesting that increasing HC\/MTL decline results in less exploratory viewing patterns. These findings reveal the ongoing influence of the hippocampus and its extended system on moment\u2010to\u2010moment naturalistic viewing.<\/jats:p>","DOI":"10.1002\/hipo.70037","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T07:10:31Z","timestamp":1759216231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Changes in Naturalistic Viewing in Healthy Aging and Amnestic Mild Cognitive Impairment"],"prefix":"10.1002","volume":"35","author":[{"given":"Anisha","family":"Khosla","sequence":"first","affiliation":[{"name":"Rotman Research Institute Baycrest Academy for Research and Education  Toronto Ontario Canada"},{"name":"Department of Psychology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana S.","family":"Wynn","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Victoria  Victoria British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arber","family":"Kacollja","sequence":"additional","affiliation":[{"name":"Vector Institute for Artificial Intelligence  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaheh","family":"Shahmiri","sequence":"additional","affiliation":[{"name":"International University of the Health Sciences University in Basseterre  Basseterre Saint Kitts and Nevis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole D.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Rotman Research Institute Baycrest Academy for Research and Education  Toronto Ontario Canada"},{"name":"Department of Psychology University of Toronto  Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Shen","sequence":"additional","affiliation":[{"name":"Institute for Neuroscience and Neurotechnology Simon Fraser University  Burnaby British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9244-7851","authenticated-orcid":false,"given":"Jennifer D.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Rotman Research Institute Baycrest Academy for Research and Education  Toronto Ontario Canada"},{"name":"Department of Psychology University of Toronto  Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278\u20107393.25.4.997"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr406"},{"key":"e_1_2_5_4_1","unstructured":"Borji A. andL.Itti.2015.\u201cCAT2000: A Large Scale Fixation Dataset for Boosting Saliency Research (Version 1)\u201darXiv.https:\/\/doi.org\/10.48550\/ARXIV.1505.03581."},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520\u2010019\u201001121\u2010w"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/pag0000683"},{"key":"e_1_2_5_7_1","volume-title":"Memory, Amnesia, and the Hippocampal System","author":"Cohen N. J.","year":"1993"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cognition.2018.12.014"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010018\u20100382\u2010y"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.14330"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.048124.118"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1302351110"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cognition.2024.105835"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab332"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.06.027"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2018.07.032"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_01336"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.220398097"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.70054"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.020"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00221"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.04.025"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010200141"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi044"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161241"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1162\/netn_a_00120"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14256"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2013.00010"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhac137"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102118"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_01385"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.70037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:25:20Z","timestamp":1764152720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.70037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/hipo.70037"],"URL":"https:\/\/doi.org\/10.1002\/hipo.70037","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,30]]},"assertion":[{"value":"2025-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70037"}}