{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:28:00Z","timestamp":1771036080039,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This essay describes the development of the in\u00a0vitro hippocampal slice technique and my small contributions to it and to influencing Roger Nicoll's early interests in the hippocampus and LTP. My Ph.D. work at Harvard with Timothy Teyler was on field potential studies of synaptic plasticity, including LTP, in the rat in\u00a0vitro hippocampal slice. As a postdoc, I introduced the slice preparation to Roger Nicoll's lab at UCSF but failed to interest him in LTP. Here I explain how Nicoll's scientific philosophy both motivated me to develop our first submersion slice chamber and kept him from investigating LTP for nearly a decade. Finally, I recount the history of the name \u201cLTP.\u201d<\/jats:p>","DOI":"10.1002\/hipo.70047","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:24:16Z","timestamp":1761827056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Notes on the History of In\u00a0Vitro Hippocampal Electrophysiology and\n                    <scp>LTP<\/scp>\n                    : Personal Reflections"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2385-9876","authenticated-orcid":false,"given":"Bradley E.","family":"Alger","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Physiology University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2023.0218"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90858-1"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00234087"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1257783"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23665"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1973.sp010274"},{"key":"e_1_2_13_8_1","first-page":"61","article-title":"Plasticity in a Monosynaptic Cortical Pathway","volume":"207","author":"Bliss T. V.","year":"1970","journal-title":"Journal of Physiology"},{"key":"e_1_2_13_9_1","volume-title":"Neurology and Neurobiology","author":"Bliss T. V. P.","year":"1988"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1973.sp010273"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.21.12132"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/35050030"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)00187-L"},{"key":"e_1_2_13_14_1","article-title":"Glutamate Receptors and Synaptic Plasticity in Health and Disease: A Personal Journey","author":"Collingridge G. L.","journal-title":"Hippocampus"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90697-6"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(75)90023-2"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1965.sp007549"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.138.3536.33"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.66.5.617"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1975.sp011103"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1957.sp005885"},{"issue":"277","key":"e_1_2_13_22_1","article-title":"Frequency Potentiation of Excitatory Synaptic Activity in the Dentate Gyrus of the Hippocampal Formation","volume":"68","author":"L\u00f8mo T.","year":"1966","journal-title":"Acta Physiologica Scandinavica"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021115-105257"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23664"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/263151a0"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/305719a0"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/321175a0"},{"key":"e_1_2_13_29_1","volume-title":"101 Theory Drive: A Neuroscientist's Quest for Memory","author":"McDermott T.","year":"2010"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0490382"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0530412"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90030-6"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23672"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.12.015"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(81)90049-2"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/258625a0"},{"key":"e_1_2_13_37_1","first-page":"2877","article-title":"Synaptic Memory and CaMKII","volume":"103","author":"Nicoll R. A.","year":"2024","journal-title":"Physiological Reviews"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1970.sp009294"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012206"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90817-3"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90138-9"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(71)90508-7"},{"key":"e_1_2_13_43_1","article-title":"Updating the Lamellar Hypothesis of Hippocampal Organization","volume":"10","author":"Sloviter R. S.","year":"2012","journal-title":"Frontiers in Neural Circuits"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90358-9"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.3.3.219"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071249"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.155.3760.341"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/2101055a0"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.70047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:25:39Z","timestamp":1764152739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.70047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/hipo.70047"],"URL":"https:\/\/doi.org\/10.1002\/hipo.70047","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]},"assertion":[{"value":"2025-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70047"}}