{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T08:44:09Z","timestamp":1776242649798,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The taiep rat originated from a spontaneous mutation in a colony of Sprague\u2013Dawley rats, whose phenotype is inherited as an autosomal recessive trait. The mutant taiep rat shows hypomyelination and demyelination of the central nervous system (CNS) and has been considered a chronic animal model of multiple sclerosis and tubulinopathies. Unlike taiep rats, heterozygous rats for the mutation (+\/\u2212), referred to as carriers, have not been widely studied. Thus, the objective of the present study was to examine the dendritic arborization and dendritic spine density of CA1 and CA3 pyramidal neurons of taiep mutation carriers. We evaluated the following groups: Sprague\u2013Dawley rats as a control (SD), mutation carriers (Carrier), and taiep rats (taiep). The brains of the animals were processed using the Golgi\u2010Cox technique to analyze the basilar and apical dendritic arborization and dendritic spine density of CA1 and CA3 pyramidal neurons. We observed a decrease in dendritic arborization in the basilar arbors of dorsal hippocampal CA1 and CA3 pyramidal neurons in both carrier and taiep adult rats, as well as a decrease in dendritic arborization in the apical arbors of CA3 neurons in carrier rats. Moreover, dendritic spine density was reduced in CA1 neurons in both rats. These results show that even when rats are mutation carriers, they exhibit alterations in the dendritic arborization of dorsal hippocampal neurons similar to those of taiep rats.<\/jats:p>","DOI":"10.1002\/hipo.70080","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:50:01Z","timestamp":1770976201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Male Rats Carrying the Taiep Mutation Show Alterations in the Dendritic Arborization of\n                    <scp>CA1<\/scp>\n                    and\n                    <scp>CA3<\/scp>\n                    Neurons"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4645-7087","authenticated-orcid":false,"given":"Fernanda","family":"Medina\u2010Flores","sequence":"first","affiliation":[{"name":"Laboratorio de Neurofisiolog\u00eda Experimental, Facultad de Ciencias Biol\u00f3gicas Benem\u00e9rita Universidad Aut\u00f3noma de Puebla  Puebla Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6284-5222","authenticated-orcid":false,"given":"Dolores Adriana","family":"Bravo\u2010Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofisiolog\u00eda Experimental, Facultad de Ciencias Biol\u00f3gicas Benem\u00e9rita Universidad Aut\u00f3noma de Puebla  Puebla Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9302-5500","authenticated-orcid":false,"given":"Ricardo","family":"Robles\u2010Soto","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofisiolog\u00eda Experimental, Facultad de Ciencias Biol\u00f3gicas Benem\u00e9rita Universidad Aut\u00f3noma de Puebla  Puebla Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0434-9168","authenticated-orcid":false,"given":"Adriana Berenice","family":"Silva\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofisiolog\u00eda Experimental, Facultad de Ciencias Biol\u00f3gicas Benem\u00e9rita Universidad Aut\u00f3noma de Puebla  Puebla Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.702039"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/DNND.S44064"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21109"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20188"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx338"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24930"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01191684"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/NIB\u2010140081"},{"key":"e_1_2_11_10_1","first-page":"11","article-title":"El mutante de mielina taiep como un modelo de crisis de ausencia","volume":"146","author":"Eguibar J. R.","year":"2010","journal-title":"Gaceta M\u00e9dica de M\u00e9xico"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.03.020"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","unstructured":"Fuenzalida M. E.Aliaga V.Olivares M.Roncagliolo andC.Bonansco.2009. \u201cDevelopmental Increase of Asynchronic Glutamate Release From Hippocampal Synapses in Mutant Taiep Rat Synapse.\u201d63:502\u2013509.https:\/\/doi.org\/10.1002\/syn.20622.","DOI":"10.1002\/syn.20622"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0165\u20100270(97)00163\u20105"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010016\u20100332\u2010x"},{"issue":"3","key":"e_1_2_11_15_1","first-page":"226","article-title":"Sprague Dawley Rat Mutant With Tremor, Ataxia, Tonic Immobility Episodes, Epilepsy and Paralysis","volume":"39","author":"Holmgren B.","year":"1989","journal-title":"Laboratory Animal Science"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21651"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000412"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0149\u20107634(97)00008\u20100"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006\u20108993(02)04143\u20104"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.08.097"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2012.12.001"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335\u2010003\u20102302\u2010z"},{"key":"e_1_2_11_23_1","first-page":"1","article-title":"Pleiotropy: One Gene Can Affect Multiple Traits","volume":"1","author":"Lobo I.","year":"2008","journal-title":"Nature Education"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23473"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471\u20104159.1997.69020773.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2009.05.009"},{"key":"e_1_2_11_27_1","first-page":"29","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos G.","year":"1998"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165\u20103806(92)90030\u2010z"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/171387a0"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.22024"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006\u20108993(03)03042\u20107"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1007060832459"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.70080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hipo.70080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.70080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:48:08Z","timestamp":1776239288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.70080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/hipo.70080"],"URL":"https:\/\/doi.org\/10.1002\/hipo.70080","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]},"assertion":[{"value":"2026-02-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70080"}}