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ORM consolidation depends on \u03b2\u2010adrenergic receptor (\u03b2AR) signaling and is associated with increased BDNF expression in the dorsal hippocampus. Although hippocampal activation of cannabinoid type\u20101 receptors (CB1Rs) is known to impair ORM consolidation, the mechanisms underlying this effect remain unclear. In this study, we used the novel object recognition task to examine the interaction between CB1Rs and \u03b2ARs during ORM consolidation in adult male Wistar rats. Intra\u2010dorsal CA1 infusion of the CB1R agonist ACEA, the \u03b2AR antagonist propranolol, or the PKA inhibitor myristoylated PKI\n                    <jats:sub>14\u201322<\/jats:sub>\n                    , administered 5\u2010min post\u2010training, impaired ORM consolidation. Notably, co\u2010administration of the PKA activator 8Br\u2010cAMP or the \u03b2AR agonist isoproterenol reversed ACEA\u2010induced amnesia. In contrast, the CB1R inverse agonist AM251 failed to reverse propranolol\u2010induced amnesia, which was instead rescued by recombinant BDNF infusion into the hippocampus 120\u2010min post\u2010training. These findings suggest that hippocampal CB1Rs regulate ORM consolidation by acting upstream of \u03b2ARs via a signaling cascade involving PKA activation and BDNF expression.\n                  <\/jats:p>","DOI":"10.1002\/hipo.70084","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:27:28Z","timestamp":1771054048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Upstream\n                    <scp>CB1R<\/scp>\n                    Regulation of \u03b2\u2010Adrenergic Memory Consolidation"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7980-5842","authenticated-orcid":false,"given":"Janine I.","family":"Rossato","sequence":"first","affiliation":[{"name":"Memory Research Laboratory\u2014Brain Institute, UFRN  Natal Rio Grande do Norte 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