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The tail's clinical relevance and volumetric variability exhibit a need for improved characterization with high\u2010resolution imaging and histology at baseline. MRI provides three\u2010dimensional context without missing slices and histology validates with architecture; combining these methods provides an optimal approach. Twenty control brain hemispheres were evaluated, including 10 males and 10 females. We scanned the hemispheres using ex\u00a0vivo MRI at 120\u2009\u03bcm isotropic resolution. The tissue was then processed and histologically stained. We manually labeled the hippocampal tail in high\u2010resolution MRI, using six distinct coronal levels of the tail as guideposts, validating histologically. The volume and length of the tails were calculated using 3D MRI reconstructions; the median tail volume (median\u2009\u00b1\u2009interquartile range) of our sample set was 715.6\u2009\u00b1\u2009227.5\u2009mm\n                    <jats:sup>3<\/jats:sup>\n                    . These data contribute a validated hippocampal tail volume. We calculated and quantified the medial flexure of the tail and compared sex as a biological variable. Male tail samples exhibited significantly larger angles than female samples (Mann\u2013Whitney U test,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01). Our findings enable precise hippocampal tail delineation and may facilitate future research on function and mental health disorders.\n                  <\/jats:p>","DOI":"10.1002\/hipo.70101","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:58:28Z","timestamp":1778659108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantitative and Morphometric Measures in the Human Hippocampal Tail Using Ex\u00a0Vivo Imaging Validated With Histology"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0017-3186","authenticated-orcid":false,"given":"Anne M.","family":"Alexander","sequence":"first","affiliation":[{"name":"Athinoula A. 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Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital  Charlestown Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1927-047X","authenticated-orcid":false,"given":"Erin\u2010Marie C.","family":"Smith","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4928-9744","authenticated-orcid":false,"given":"Chiara","family":"Mauri","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital  Charlestown Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2413-1115","authenticated-orcid":false,"given":"Bruce","family":"Fischl","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital  Charlestown Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruopeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3940-9861","authenticated-orcid":false,"given":"Matthew P.","family":"Frosch","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2754-6594","authenticated-orcid":false,"given":"Andr\u00e9 J. W.","family":"van der Kouwe","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital  Charlestown Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-6671","authenticated-orcid":false,"given":"Jean C.","family":"Augustinack","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital  Charlestown Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801093115"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235381"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195100273.001.0001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20426"},{"issue":"1","key":"e_1_2_11_6_1","first-page":"30","article-title":"Memory and Neurogenesis in Aging and Alzheimer's Disease","volume":"1","author":"Avila J.","year":"2010","journal-title":"Aging and Disease"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010020\u201000279\u20106"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2017.04.036"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg034"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.05.022"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4088\/jcp.v69n0707"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010006\u20100127\u2010z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.262"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010024\u201005630\u20105"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.76143"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23172"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116328"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23786"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1351"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920\u20101211(93)90083\u2010j"},{"issue":"10","key":"e_1_2_11_22_1","first-page":"2702","article-title":"The Human Hippocampus: Functional Anatomy, Vascularization and Serial Sections With MRI, 3rd Edition","volume":"26","author":"Duvernoy H.","year":"2005","journal-title":"AJNR. 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