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AD patients exhibit stress system abnormalities including upregulation of the corticotropin releasing factor type 1 receptor (CRF\n                    <jats:sub>1<\/jats:sub>\n                    ) and elevated cortisol. Psychological distress increases the likelihood of AD diagnosis and hastens neurocognitive decline. Administration of the CRF\n                    <jats:sub>1<\/jats:sub>\n                    antagonist, Antalarmin, reduces AD pathogenesis and anxiety\u2010like behavior in models of AD. Motivated by these observations, the current study examined the potential contributions of CRF\n                    <jats:sub>1<\/jats:sub>\n                    to altered synaptic plasticity in AD neuropathology and stress in the TgF344\u2010AD rat model. In\u00a0vivo electrophysiological recordings to assess long\u2010term potentiation (LTP) in the perforant pathway to dentate gyrus synapses were performed in aged transgenic rats and wild\u2010type (WT) controls (2\u20132.5\u2009years). TgF344\u2010AD rats had abnormal LTP measures of field excitatory post\u2010synaptic potentials (fEPSP) and population spikes (PS). Treatment with Antalarmin did not alter LTP measures in TgF344\u2010AD or WT rats. These observations indicate that LTP in TgF344\u2010AD rats is reduced compared to WT rats and that acute treatment with a CRF\n                    <jats:sub>1<\/jats:sub>\n                    antagonist did not rescue LTP deficits. Future research should further examine the mechanism of CRF\n                    <jats:sub>1<\/jats:sub>\n                    in AD and implications of agonism or direct infusions of Antalarmin in\u00a0vivo.\n                  <\/jats:p>","DOI":"10.1002\/hipo.70103","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:10:22Z","timestamp":1779336622000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Corticotropin\u2010Releasing Factor 1 Receptor Antagonism on In\u00a0Vivo Dentate Gyrus Long\u2010Term Potentiation in the\n                    <scp>TgF344<\/scp>\n                    \u2010\n                    <scp>AD<\/scp>\n                    Rat Model of Alzheimer's Disease"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2324-8688","authenticated-orcid":false,"given":"Nicole 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