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Here, we examined how activation of hippocampal NOP receptors influences distinct stages of object recognition memory (ORM) processing. Adult male Wistar rats trained in the novel object recognition task received bilateral intra\u2010dorsal CA1 infusions of N\/OFQ either 20\u2009min before or 5\u2009min after training, or 20\u2009min before a 1\u2010day retention test. Pre\u2010training N\/OFQ infusion markedly impaired ORM retention without affecting locomotor or exploratory behavior, whereas post\u2010training or pre\u2010test infusions had no effect, even at more than threefold higher. The selective NOP receptor antagonist UFP\u2010101 completely blocked the amnesic effect of N\/OFQ but had no influence alone. Pre\u2010training N\/OFQ administration also failed to alter performance in the step\u2010down inhibitory avoidance task, excluding sensory or motivational confounds. Thus, hippocampal NOP receptor activation selectively disrupts ORM acquisition while sparing consolidation and recall, identifying the N\/OFQ\u2010NOP system as a negative modulator of hippocampal encoding mechanisms critical for recognition memory formation.<\/jats:p>","DOI":"10.1002\/hipo.70104","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T05:05:14Z","timestamp":1779512714000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hippocampal\n                    <scp>NOP<\/scp>\n                    Receptor Activation Impairs Object Recognition Memory Acquisition"],"prefix":"10.1002","volume":"36","author":[{"given":"Lucas","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Memory Research Laboratory \u2010 Brain Institute, UFRN  Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Orvate","sequence":"additional","affiliation":[{"name":"Memory Research Laboratory \u2010 Brain Institute, UFRN  Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johseph P.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Memory Research Laboratory \u2010 Brain Institute, UFRN  Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luizi","family":"Baracho","sequence":"additional","affiliation":[{"name":"Memory Research Laboratory \u2010 Brain Institute, UFRN  Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00eanedy","family":"Apolinario","sequence":"additional","affiliation":[{"name":"Memory Research Laboratory \u2010 Brain Institute, UFRN  Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"Cammarota","sequence":"additional","affiliation":[{"name":"Memory Research Laboratory \u2010 Brain Institute, UFRN  Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7980-5842","authenticated-orcid":false,"given":"Janine I.","family":"Rossato","sequence":"additional","affiliation":[{"name":"Memory Research Laboratory \u2010 Brain Institute, UFRN  Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2017.09.005"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj114"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0306\u20104522(98)00683\u20106"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010025\u201006842\u20107"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1650110"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527\u20103458.2005.tb00264.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.07.002"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/81.1.29"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010023\u201002363\u2010x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2023.107841"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006\u20108993(00)02669\u2010x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735\u20107044.122.1.98"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3711\u201007.2008"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2019.04.015"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460\u20109568.2002.01926.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2572"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.01.028"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001313"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/29073"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010002\u20100661\u20108"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20106997(24)01502\u20103"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2011.627071"},{"key":"e_1_2_5_24_1","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos G. 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