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While hippocampal time cells and entorhinal temporal context cells are well\u2010established in\u00a0vivo, it remains unclear whether single neurons can sustain representations of elapsed time over multi\u2010second intervals, independent of synaptic drive. Here, using whole\u2010cell patch\u2010clamp recordings in rat hippocampal CA1 slices under synaptic blockade, we show that following a brief current pulse, many neurons exhibit exponentially decaying firing rates with a broad distribution of time constants extending to tens of seconds. This indicates that single neurons possess intrinsic mechanisms capable of covering behaviorally relevant temporal scales. These results highlight that single neurons can encode temporal information over more than an order of magnitude, providing a potential cellular substrate for temporal coding in the brain.<\/jats:p>","DOI":"10.1002\/hipo.70105","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:28:22Z","timestamp":1781497702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intrinsic Persistent Firing in\n                    <scp>CA1<\/scp>\n                    Encodes Elapsed Time Across Behaviorally Relevant Scales"],"prefix":"10.1002","volume":"36","author":[{"given":"Sara","family":"Zomorodi","sequence":"first","affiliation":[{"name":"Department of Computer Science Indiana University  Bloomington Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Knauer","sequence":"additional","affiliation":[{"name":"International Graduate School of Neuroscience (IGSN) Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yacine","family":"Brahimi","sequence":"additional","affiliation":[{"name":"Functional Architecture of Memory Leibniz Institute for Neurobiology (LIN)  Magdeburg Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  Magdeburg Germany"},{"name":"Medical Faculty, Otto\u2010von\u2010Guericke Universit\u00e4t (OvGU)  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Reboreda","sequence":"additional","affiliation":[{"name":"Functional Architecture of Memory Leibniz Institute for Neurobiology (LIN)  Magdeburg Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoharu","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Functional Architecture of Memory Leibniz Institute for Neurobiology (LIN)  Magdeburg Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  Magdeburg Germany"},{"name":"Center for Behavioral Brain Sciences (CBBS)  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Tiganj","sequence":"additional","affiliation":[{"name":"Department of Computer Science Indiana University  Bloomington Indiana USA"},{"name":"Department of Psychological and Brain Sciences Indiana University  Bloomington Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00234.2024"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10827-024-00891-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.277814"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0479-22.2023"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1917197117"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.75353"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2404169121"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23282"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1162\/neco.1993.5.4.613"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01171"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3827"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn834"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.01.036"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00228702"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.108972.1.sa3"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00267"},{"issue":"8","key":"e_1_2_9_18_1","first-page":"E1089","article-title":"Cortical Cholinergic Signaling Controls the Detection of Cues","volume":"113","author":"Gritton H. 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