{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:33:44Z","timestamp":1790922824612,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 MH118545"],"award-info":[{"award-number":["R01 MH118545"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 MH112613"],"award-info":[{"award-number":["R01 MH112613"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DA055259"],"award-info":[{"award-number":["R01 DA055259"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2038235"],"award-info":[{"award-number":["2038235"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Contextual information, such as spatial locations and social groups, are known to propagate reward\u2010seeking behavior including binge drinking. Animal models suggest that context\u2010evoked drug and alcohol seeking emerges from hippocampal projections to the ventral striatum (i.e., nucleus accumbens). While binge drinking has been associated with adverse structure and function of both the ventral striatum and hippocampus, the anatomical relevance of this circuit in humans has largely been inferred from volumetric studies investigating these regions separately. Using diffusion MRI tractography in adults ages 22\u201335 (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009593), we examined hippocampal\u2013ventral striatum (HPC\u2010VS) connectivity in relation to binge drinking. We found that greater left hemisphere HPC\u2010VS connectivity was associated with greater past\u2010year binge drinking frequency (\n                    <jats:italic>b<\/jats:italic>\n                    \u2009=\u20090.17,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027). In the right\u2010hemisphere, an HPC\u2010VS\u2009\u00d7\u2009sex interaction emerged for binge drinking frequency (\n                    <jats:italic>b<\/jats:italic>\n                    \u2009=\u20090.17,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.031), such that greater right\u2010hemisphere connectivity was associated with greater binge drinking frequency in females but lower binge drinking frequency in males. These findings demonstrate hemisphere\u2010 and sex\u2010specific associations between hippocampal\u2010striatal pathways and alcohol use, implicating structural variability in this circuit as a correlate of vulnerability to alcohol consumption that may be problematic.\n                  <\/jats:p>","DOI":"10.1002\/hipo.70113","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T17:25:52Z","timestamp":1785000352000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hippocampus\u2013Ventral Striatum Connectivity Is Associated With Binge Drinking Frequency in Adults"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6832-5819","authenticated-orcid":false,"given":"Blake L.","family":"Elliott","sequence":"first","affiliation":[{"name":"Department of Psychology and Neuroscience Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeeshan M.","family":"Huque","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1747-2616","authenticated-orcid":false,"given":"Nicholas A.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Ellman","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu P.","family":"Murty","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Oregon  Eugene Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.56.4.356"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2013.03.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.669075"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.116.5.884"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep32833"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00037"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1075"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471725153"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2010.05896.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010019\u20100594\u20102"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20103223(02)01546\u20109"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521\u20100391.2010.00057.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01384-w"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0087-23.2023"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1994.55.149"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0100-24.2024"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0014414"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i11.1377"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010025\u201003660\u20105"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2021.05.002"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0945-22.2022"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23608"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.12.16.628816"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.08.023"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2023.100540"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010020\u20100650\u2010y"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.03.003"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01204-1"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2022.10.004"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-19425-7"},{"key":"e_1_2_6_32_1","unstructured":"Harrell F. E. Jr.2026.\u201crms: Regression Modeling Strategies (R Package Version 8.1\u20101).\u201dhttps:\/\/CRAN.R\u2010project.org\/package=rms."},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2004.02.001"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550040099019"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112678"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.07.039"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2018.03.009"},{"issue":"13","key":"e_1_2_6_38_1","first-page":"2459","article-title":"Ethanol Experience Enhances Glutamatergic Ventral Hippocampal Inputs to D1 Receptor\u2010Expressing Medium Spiny Neurons in the Nucleus Accumbens Shell","volume":"39","author":"Kircher D. M.","year":"2019","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0740-8"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.05.002"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02332-1"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqae088"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4299-15.2016"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.05.037"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2018.02.006"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2006.10.010"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14147"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471\u20104159.2002.01214.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2025.07.010"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.2.188"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.10.039"},{"issue":"3","key":"e_1_2_6_52_1","first-page":"185","article-title":"Drinking Among Young Adults: Prevalence, Patterns, and Consequences","volume":"20","author":"Quigley L. A.","year":"1996","journal-title":"Alcohol Health & Research World"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369\u20101600.2012.00464.x"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22542"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00247"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1159\/000534620"},{"key":"e_1_2_6_57_1","unstructured":"Substance Abuse and Mental Health Services Administration.2024.\u201cKey Substance Use and Mental Health Indicators in the United States: Results From the 2023 National Survey on Drug Use and Health (HHS Publication No. PEP24\u201007\u2010021 NSDUH Series H\u201059).\u201dCenter for Behavioral Health Statistics and Quality Substance Abuse and Mental Health Services Administration.https:\/\/www.samhsa.gov\/data\/report\/2023\u2010nsduh\u2010annual\u2010national\u2010report."},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs397"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24625"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3371-07.2007"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.1996.tb05936.x"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010654108"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7394532"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717000721"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.07121877"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.35946\/arcr.v38.2.04"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.09.007"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.70113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hipo.70113","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.70113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T07:40:39Z","timestamp":1785138039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.70113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/hipo.70113"],"URL":"https:\/\/doi.org\/10.1002\/hipo.70113","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70113"}}