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However, the evolutionary principles governing changes in brain connectivity and their impact on cognition remain poorly understood. In the current study, we analyzed differences in anatomical input from the cerebral cortex to the hippocampal region across six species spanning more than 100 million years of mammalian evolution\u2014the tenrec, rat, cat, marmoset, macaque and human. Our results demonstrate that, unlike direct transmodal cortical input, direct unimodal cortical input to the hippocampal region was selectively eliminated with the increase in brain size. Additionally, input from primary sensory regions was eliminated prior to input from non\u2010primary sensory regions. Our findings suggest that hippocampus\u2010related processes in different species operate on fundamentally different types of information, potentially underpinning cross\u2010species differences in hippocampus\u2010dependent cognition. Furthermore, our findings outline the evolutionary trajectory of the anatomical circuitry associating the human hippocampal region with the neocortex.<\/jats:p>","DOI":"10.1002\/hipo.70119","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:23:24Z","timestamp":1788495804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phylogeny of Cortical\u2010Hippocampal Projections Reveals Selective Elimination of Input From Sensory Regions"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6578-5692","authenticated-orcid":false,"given":"Daniel","family":"Reznik","sequence":"first","affiliation":[{"name":"Kavli Institute for Systems Neuroscience, Centre for Algorithms in the Cortex, NTNU  Trondheim Norway"},{"name":"Oxford Centre for Integrative Neuroimaging University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9055-8686","authenticated-orcid":false,"given":"Piotr","family":"Majka","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroinformatics Nencki Institute of Experimental Biology of the Polish Academy of Sciences  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6620-6285","authenticated-orcid":false,"given":"Marcello G. 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