{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:04:52Z","timestamp":1790323492892,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008688","name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["UNAM DGAPA\u2010PAPIIT IN207123"],"award-info":[{"award-number":["UNAM DGAPA\u2010PAPIIT IN207123"]}],"id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Viral infections during critical periods of pregnancy trigger inflammatory responses that alter offspring brain development\u00a0and behavior, resulting in psychiatric disorder\u2010associated phenotypes. This condition is commonly referred to as prenatal stress\u00a0induced by maternal immune activation (MIA). Here, we investigate the effects of MIA on the neurophysiological\u00a0properties of the dentate gyrus\u2010CA3 circuit, a hippocampal circuit critical for cortical input processing and memory\u00a0formation, and increasingly implicated in psychiatric disorders. Pregnant Sprague\u2013Dawley dams were systemically administered polyinosinic:polycytidylic acid (poly I:C), a synthetic double\u2010stranded RNA that elicits a viral\u2010like immune response\u00a0by activating the Toll\u2010like receptor 3 (TLR3)\u2010NF\u2010kB signaling pathway. Extracellular recordings were performed on acute slices\u00a0of male offspring at postnatal days 61\u201380. MIA increased the antidromic population spike amplification at the mossy fiber (MF)\u2010granule cell layer response without modifying the antidromic responses at the CA3\u2010CA3 commissural\u2010associational fibers. Paired pulses with short interstimulus intervals revealed decreased levels of phasic and tonic GABAergic\u00a0inhibition. In addition, MIA reduced coupling between presynaptic fiber volleys and MF field excitatory postsynaptic potentials (MF fEPSP). At the level of synaptic plasticity, MIA impaired frequency\u2010dependent facilitation and decreased MF fEPSP paired\u2010pulse facilitation, two hallmark forms of short\u2010term plasticity at the MF\u2010CA3 synapse. Lastly, MF\u2010mediated long\u2010term potentiation (MF LTP) and long\u2010term depression (MF LTD) showed altered magnitudes in MIA slices. Collectively, our results indicate that MIA alters neuronal processing and output in the DG\u2010CA3 hippocampal network, supporting the contribution of maternal inflammation to long\u2010term circuit dysfunction associated with viral infections during pregnancy.<\/jats:p>","DOI":"10.1002\/hipo.70132","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:50:26Z","timestamp":1789995026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal Stress Induced by Maternal Immune Activation Disrupts\n                    <scp>GABAergic<\/scp>\n                    Inhibition and Mossy Fiber Plasticity in the Rat Dentate Gyrus\u2010CA3 Circuit"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7259-8552","authenticated-orcid":false,"given":"Johaly","family":"Anguiano\u2010Buenfil","sequence":"first","affiliation":[{"name":"Departamento de Farmacobiolog\u00eda CINVESTAV Sur  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4569-3643","authenticated-orcid":false,"given":"Isabel","family":"Sollozo\u2010Dupont","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Perinatolog\u00eda, Isidro Espinosa de los Reyes  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8791-3504","authenticated-orcid":false,"given":"Luis A.","family":"M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacobiolog\u00eda CINVESTAV Sur  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0857-1652","authenticated-orcid":false,"given":"Angelica","family":"Zepeda","sequence":"additional","affiliation":[{"name":"Departmento de Medicina Gen\u00f3mica y Toxicolog\u00eda Ambiental Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9820-302X","authenticated-orcid":false,"given":"Emilio J.","family":"Galv\u00e1n","sequence":"additional","affiliation":[{"name":"Departamento de Farmacobiolog\u00eda CINVESTAV Sur  Ciudad de M\u00e9xico M\u00e9xico"},{"name":"Cento de Investigaciones sobre el Envejecimiento, CIE\u2010Cinvestav  Ciudad de M\u00e9xico 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