{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T21:45:40Z","timestamp":1761428740300},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,24]],"date-time":"2004-10-24T00:00:00Z","timestamp":1098576000000},"content-version":"vor","delay-in-days":20385,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helvetica Chimica Acta"],"published-print":{"date-parts":[[1949,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Es wurde eine Reihe von 1,2,3,4\u2010Tetraalkyl\u20105\u2010pyrazolonen dargestellt. Diese Verbindungen sind weder antipyretisch noch analgetisch wirksam. Dieser Befund l\u00e4sst die Schlussfolgerung zu, dass f\u00fcr die gesuchte therapeutische Wirkung der Pyrazolone ein am N<jats:sub>1<\/jats:sub>\u2010gebundener aliphatischer Rest nicht gen\u00fcgt.<\/jats:p>","DOI":"10.1002\/hlca.19490320347","type":"journal-article","created":{"date-parts":[[2004,12,26]],"date-time":"2004-12-26T23:35:48Z","timestamp":1104104148000},"page":"984-992","source":"Crossref","is-referenced-by-count":8,"title":["N,N\u2032\u2010Dialkyl\u2010pyrazolone"],"prefix":"10.1002","volume":"32","author":[{"given":"J.","family":"B\u00fcchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ursprung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lauener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,24]]},"reference":[{"key":"e_1_2_1_1_2","first-page":"2597","volume":"16","author":"Knorr","year":"1883","journal-title":"B."},{"key":"e_1_2_1_1_3","first-page":"549","volume":"17","year":"1884","journal-title":"B."},{"key":"e_1_2_1_2_2","unstructured":"F\u00fcr Einzelheiten verweisen wir auf die Dissertation \u201cSynthesen in der Pyrazolonreiht\u201d vonR.Ursprung E.T.H. (1948)."},{"key":"e_1_2_1_3_2","first-page":"405","volume":"1939","author":"Kitamura","journal-title":"C."},{"key":"e_1_2_1_3_3","first-page":"741","volume":"1940","journal-title":"C."},{"key":"e_1_2_1_4_2","unstructured":"Die Numerierung der Ringglieder geht von dem den gr\u00f6sseren Substitutnten tragenden Heteroatom aus."},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1248\/yakushi1881.57.11_953","volume":"57","author":"Sawa","year":"1937","journal-title":"Journ. pharm. Soc."},{"key":"e_1_2_1_6_2","first-page":"2354","volume":"31","author":"Yano","year":"1937","journal-title":"Chem. Abstr."},{"key":"e_1_2_1_7_2","unstructured":"H\u00f6hst DRP. 92009 (1896)."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01849a077"},{"key":"e_1_2_1_8_3","doi-asserted-by":"publisher","DOI":"10.1021\/ja01853a008"},{"key":"e_1_2_1_9_2","unstructured":"Geigy Brit. Pat. 563279."},{"key":"e_1_2_1_10_2","unstructured":"H\u00f6chst DRP. 248887 (1912)."},{"key":"e_1_2_1_11_2","unstructured":"H\u00f6chst DRP. 92009 (1896)."},{"key":"e_1_2_1_12_2","unstructured":"Oswald Chemische Konstitution und pharmakologische Wirkung 1. Auflage Berlin1924 Seite607."},{"key":"e_1_2_1_13_2","first-page":"1696","volume":"75","author":"Skite","year":"1942","journal-title":"B."},{"key":"e_1_2_1_14_2","unstructured":"I. G. E.P. 500224 (1939)."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/prac.19120850107"},{"key":"e_1_2_1_16_2","first-page":"310","volume":"3","author":"Bockm\u00fchl","year":"1936","journal-title":"Med. und Chem. I.G."},{"key":"e_1_2_1_17_2","unstructured":"Oswald Chemische Konstitution und pharmakologische Wirkung 1. Auflage Berlin1924 Seite607;"},{"key":"e_1_2_1_17_3","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.193501801101"},{"key":"e_1_2_1_18_2","first-page":"2597","volume":"16","author":"Knorr","year":"1883","journal-title":"B."},{"key":"e_1_2_1_18_3","first-page":"549","volume":"17","year":"1884","journal-title":"B."},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01432a023"},{"key":"e_1_2_1_20_2","first-page":"2736","volume":"33","author":"Wohl","year":"1900","journal-title":"B."},{"key":"e_1_2_1_21_2","first-page":"86","volume":"62","author":"Curtius","year":"1900","journal-title":"J. pr. [2]"},{"key":"e_1_2_1_22_2","first-page":"153","volume":"110","author":"von Auwers","year":"1925","journal-title":"J. pr. [2]"},{"key":"e_1_2_1_23_2","first-page":"153","volume":"110","author":"von Auwers","year":"1925","journal-title":"J. pr. [2]"},{"key":"e_1_2_1_24_2","unstructured":"Hoffmann\u2010LaRoche DRP. 565799 (1932)."},{"key":"e_1_2_1_25_2","first-page":"1582","volume":"66","author":"Sonn","year":"1933","journal-title":"B."},{"key":"e_1_2_1_26_2","unstructured":"F\u00fcr die Bezeichnung der Methoden sieche den experimentellen Teil."},{"key":"e_1_2_1_27_2","unstructured":"Diese Verbindungen krystallisieren als Semihydrate."},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01432a023"},{"key":"e_1_2_1_28_3","first-page":"2736","volume":"33","author":"Wohl","year":"1900","journal-title":"B."},{"key":"e_1_2_1_28_4","first-page":"86","volume":"62","author":"Curtius","year":"1900","journal-title":"J. pr. (2)"},{"key":"e_1_2_1_28_5","first-page":"1061","volume":"6","author":"Rupe","year":"1923","journal-title":"Helv."},{"key":"e_1_2_1_28_6","doi-asserted-by":"publisher","DOI":"10.15227\/orgsyn.018.0066"},{"key":"e_1_2_1_29_2","first-page":"253","volume":"29","author":"Knorr","year":"1896","journal-title":"B."},{"key":"e_1_2_1_30_2","unstructured":"Um ein Verdampfen des Bromides w\u00e4hrend dem Zuschmelzen des Rohres zu vermeiden wurde das Bromid in einer Ampulle eingeschmolzen und diese Ampulle im Rohr eingeschmolzen. Nach dem Zuschmelzen und Erkalten des Rohres wurde die Ampulle durch rasches Kehren des Rohres zertr\u00fcmmert. Dadurch wurde verhindert dass das Bromid zum Teil verloren ging und das oft beobachtete Entglasen des Bombenrohres auftrat. Diese Methode wandten wir bei allen Alkylierungen mit Erfolg an."},{"key":"e_1_2_1_31_2","first-page":"991","volume":"3","journal-title":"Siehe Anm."}],"container-title":["Helvetica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhlca.19490320347","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhlca.19490320347","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hlca.19490320347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T14:16:42Z","timestamp":1697725002000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hlca.19490320347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1949,1]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1949,1]]}},"alternative-id":["10.1002\/hlca.19490320347"],"URL":"https:\/\/doi.org\/10.1002\/hlca.19490320347","archive":["Portico"],"relation":{},"ISSN":["0018-019X","1522-2675"],"issn-type":[{"value":"0018-019X","type":"print"},{"value":"1522-2675","type":"electronic"}],"subject":[],"published":{"date-parts":[[1949,1]]}}}