{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T03:07:56Z","timestamp":1761620876046},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,10,25]],"date-time":"2004-10-25T00:00:00Z","timestamp":1098662400000},"content-version":"vor","delay-in-days":11310,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helvetica Chimica Acta"],"published-print":{"date-parts":[[1973,11,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Propionic acids labelled either with <jats:sup>14<\/jats:sup>C in positions 1, 2, or 3, or with <jats:sup>14<\/jats:sup>C in position 1 and <jats:sup>3<\/jats:sup>H in position 3 have been used as precursors in biosynthesis of rifamycins by <jats:italic>Streptomyces mediterranei<\/jats:italic>. The resulting distribution of radioactivity in rifamycins S \u2013 as determined by systematic degradation \u2013 shows that 23 of the 37 carbon atoms in rifamycin S originate from propionic acid. This result and the distribution pattern of radioactivity are in agreement with those obtained recently by <jats:sup>13<\/jats:sup>C\u2010NMR. spectroscopy [7].<\/jats:p><jats:p>The S\u2010methyl groups of methionin, labelled with <jats:sup>14<\/jats:sup>C, are incorporated in rifamycins by <jats:italic>Streptomyces mediterranei<\/jats:italic> only in the methoxy group.<\/jats:p><jats:p>The consequences of these findings for the biogenesis of other ansamycins, <jats:italic>e.g<\/jats:italic>. streptovaricins, are discussed. The similarities in the constitution and configuration of ansamycins and macrolides (<jats:italic>cf<\/jats:italic>. [9]) indicate that all these microbial metabolites are formed according to the same biogenetic pattern.<\/jats:p>","DOI":"10.1002\/hlca.19730560718","type":"journal-article","created":{"date-parts":[[2004,12,26]],"date-time":"2004-12-26T17:43:04Z","timestamp":1104082984000},"page":"2315-2323","source":"Crossref","is-referenced-by-count":25,"title":["\u00dcber die Biogenese des Rifamycins S"],"prefix":"10.1002","volume":"56","author":[{"given":"Mario","family":"Brufani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Kluepfel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Carlo","family":"Lancini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Leitich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert Sergeevitch","family":"Mesentsev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Prelog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fritz Peter","family":"Schmook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Sensi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,25]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19730560717"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-395530-2.50011-1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19560680104"},{"key":"e_1_2_1_4_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19570690109"},{"key":"e_1_2_1_5_2","first-page":"186","volume":"14","author":"Birch A. 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