{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T23:10:41Z","timestamp":1776726641619,"version":"3.51.2"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,9,4]],"date-time":"2011-09-04T00:00:00Z","timestamp":1315094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The translocation (9;22) (q34;q11), known as the Philadelphia (Ph) chromosome and <jats:italic>bcr\u2010abl<\/jats:italic> fusion gene, is the common cytogenetic abnormality and an unfavourable prognosis in adult acute lymphoblastic leukaemia (ALL). Although chemotherapeutic treatment produced high rates of complete response in approximately 70%\u201380% of newly diagnosed Ph+ ALL, the onset of resistance and clinical relapse is rapid. Therefore, the efficacy of treatment in Ph+ ALL is still to be determined. In this study, we aimed to assess the antileukemic activity of rapamycin (RAPA) (Sigma\u2010Aldrich Corporation, MO, USA), a mammalian target of rapamycin inhibitor, alone and in combination with daunorubicin (DNR) (Pharmacia &amp; Upjohn Company, Germany) in a Ph+ acute lymphoblastic cell line SUP\u2010B15 and a primary Ph+ ALL sample in vitro. Here, we demonstrated that 50\u2009nmol\/L of RAPA significantly intensified the inhibition induced by DNR on both Ph+ ALL cell line and a primary Ph+ ALL sample. Notably, we reported that the consequence of DNR treatment induced the over expression of the componets of mammalian target of rapamycin signalling pathway, whereas RAPA effectively eliminated this deleterious side effect of DNR, which might enhance DNR's ability to kill drug\u2010resistant cancer. The synergistic effect was also associated with the increase in autophagy, blockage of cell cycle progression in the G1 phase. Altogether, our results suggest that DNR in combination with RAPA is more effective in the treatment of Ph+ ALL compared with DNR alone. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.1013","type":"journal-article","created":{"date-parts":[[2011,9,5]],"date-time":"2011-09-05T01:50:47Z","timestamp":1315187447000},"page":"123-130","source":"Crossref","is-referenced-by-count":8,"title":["Antileukaemia effect of rapamycin alone or in combination with daunorubicin on ph+ acute lymphoblastic leukaemia cell line"],"prefix":"10.1002","volume":"30","author":[{"given":"Xi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Hematology, State Key Laboratory of Biotherapy and Cancer Center West China Hospital of Sichuan University  Chengdu China 610041"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Hematology, State Key Laboratory of Biotherapy and Cancer Center West China Hospital of Sichuan University  Chengdu China 610041"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuping","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Hematology, State Key Laboratory of Biotherapy and Cancer Center West China Hospital of Sichuan University  Chengdu China 610041"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Hematology, State Key Laboratory of Biotherapy and Cancer Center West China Hospital of Sichuan University  Chengdu China 610041"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Shuai","sequence":"additional","affiliation":[{"name":"Department of Hematology, State Key Laboratory of Biotherapy and Cancer Center West China Hospital of Sichuan University  Chengdu China 610041"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiqing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology, State Key Laboratory of Biotherapy and Cancer Center West China Hospital of Sichuan University  Chengdu China 610041"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hematology, State Key Laboratory of Biotherapy and Cancer Center West China Hospital of Sichuan University  Chengdu China 610041"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingqing","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Hematology, State Key Laboratory of Biotherapy and Cancer Center West China Hospital of Sichuan University  Chengdu China 610041"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangcui","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology, State Key Laboratory of Biotherapy and Cancer Center West China Hospital of Sichuan University  Chengdu China 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