{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T22:28:07Z","timestamp":1764541687629},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T00:00:00Z","timestamp":1317686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glutathione S\u2010transferases (GSTs) are phase II enzymes that detoxify hazardous xenobiotics including carcinogens. Inter\u2010individual variations in GSTM1 and GSTT1 loci have been associated with several types of cancer, including leukemias. In this study, we investigated the possible association between <jats:italic>GSTM1<\/jats:italic> and <jats:italic>GSTT1<\/jats:italic> polymorphisms and susceptibility to chronic myeloid leukemia (CML) in a Turkish population. In a case\u2010control study, 106 CML patients and 190 healthy controls were evaluated for <jats:italic>GSTM1<\/jats:italic> and <jats:italic>GSTT1<\/jats:italic> polymorphisms. GSTM1 null (<jats:italic>GSTM1<jats:sup>\u2010<\/jats:sup><\/jats:italic>) genotype frequencies in CML cases and controls were 45.3% and 42.6%, respectively. GSTT1 null (<jats:italic>GSTT1<jats:sup>\u2010<\/jats:sup><\/jats:italic>) genotype frequencies were 44.3% and 18.4%, respectively. The frequency of the <jats:italic>GSTT1<jats:sup>\u2010<\/jats:sup><\/jats:italic> genotype among CML patients was significantly higher than in controls [odds ratio (OR) 3.53, 95% confidence interval (CI) 2.08\u20106.00; P\u2009&lt;\u20090.0001]. Individuals with the <jats:italic>GSTM1<jats:sup>\u2010<\/jats:sup><\/jats:italic> genotype did not have increased risk of CML [OR: 1.11; 95% CI: 0.69\u20101.80; P\u2009=\u20090.714]. The combined <jats:italic>GSTM1<jats:sup>\u2010<\/jats:sup>\/ GSTT1<jats:sup>\u2010<\/jats:sup><\/jats:italic> genotype was significantly associated with risk of CML compared to the <jats:italic>GSTM1<jats:sup>+<\/jats:sup>\/GSTT1<jats:sup>+<\/jats:sup><\/jats:italic> genotype which was most frequent in both cases and controls [OR: 9.47; 95% CI: 3.61\u201024.87]. Similar findings have only been obtained in Turkish and Indian populations but not elsewhere. The <jats:italic>GSTM1<jats:sup>+<\/jats:sup><\/jats:italic>\/<jats:italic>GSTT1<jats:sup>\u2010<\/jats:sup><\/jats:italic> genotype was associated with a 2.5\u2010fold increased risk compared with the <jats:italic>GSTM1<jats:sup>\u2010<\/jats:sup><\/jats:italic>\/<jats:italic>GSTT1<jats:sup>+<\/jats:sup><\/jats:italic> genotype, the second most frequent genotype (OR; 2.46; 95% CI: 1.17, 5.20), suggesting a complex interaction between <jats:italic>GSTM1<\/jats:italic> and <jats:italic>GSTT1<\/jats:italic>. Our results indicate an association between the <jats:italic>GSTT1<jats:sup>\u2010<\/jats:sup><\/jats:italic> genotype, either alone or in combination with <jats:italic>GSTM1<jats:sup>\u2010<\/jats:sup><\/jats:italic> genotype, and risk of CML, suggesting a possible interaction between <jats:italic>GSTM1<\/jats:italic> and <jats:italic>GSTT1<\/jats:italic>. These findings, which are possibly restricted to Turkey and India, warrant further research. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.1018","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T09:17:34Z","timestamp":1317719854000},"page":"150-155","source":"Crossref","is-referenced-by-count":19,"title":["Variations in glutathione\u2010S\u2010transferase genes influence risk of chronic myeloid leukemia"],"prefix":"10.1002","volume":"30","author":[{"given":"Nur","family":"\u00d6zten","sequence":"first","affiliation":[{"name":"Department of Medical Biology, School of Medicine Ankara University  Ankara Turkey"},{"name":"Department of Pathology, College of Medicine University of Illinois at Chicago  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asuman","family":"Sunguro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, School of Medicine Ankara University  Ankara 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