{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:47:22Z","timestamp":1748220442749},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T00:00:00Z","timestamp":1337644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Post\u2010transplant lymphoproliferative disorders of T\u2010cell origin are quite uncommon, and the vast majority represent neoplasms of mature, post\u2010thymic T\u2010 or natural killer cells. Here, we report a rare case of T\u2010cell acute lymphoblastic leukaemia (T\u2010ALL), which occurred in an 18\u2010year\u2010old man who had undergone three liver transplants, initially for biliary atresia and subsequently for graft failure due to chronic rejection. He had received immunosuppression with cyclosporine and tacrolimus, as well as short\u2010term treatment with OKT3. The T\u2010ALL occurred 16\u2009years after the first liver transplant. This case highlights the challenge for classifying rare neoplasms occurring in recipients of solid organ transplants that are currently not recognized to lie within the spectrum of post\u2010transplant lymphoproliferative disorders. Given the long interval between the liver transplants and the development of T\u2010ALL, a coincidental occurrence of the leukaemia cannot be ruled out. However, the potential roles of immunosuppressive therapy and other co\u2010morbid conditions of the individual as possible risk factors for the pathogenesis of T\u2010ALL are discussed. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2016","type":"journal-article","created":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T19:00:56Z","timestamp":1337713256000},"page":"49-53","source":"Crossref","is-referenced-by-count":7,"title":["T\u2010cell acute lymphoblastic leukaemia after liver transplantation: post\u2010transplant lymphoproliferative disorder or coincidental <i>de novo<\/i> leukaemia?"],"prefix":"10.1002","volume":"31","author":[{"given":"Yanan","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Pathology SUNY Downstate Medical Center  Brooklyn NY 11203 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerice A","family":"Pinkney","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Columbia University Medical Center and Morgan Stanley Children's Hospital, New York Presbyterian Hospital  New York NY 10032 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Division of Hematopathology Columbia University Medical Center, New York Presbyterian Hospital  New York NY 10032 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana","family":"Gindin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Division of Hematopathology Columbia University Medical Center, New York Presbyterian Hospital  New York NY 10032 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Columbia University Medical Center and Morgan Stanley Children's Hospital, New York Presbyterian Hospital  New York NY 10032 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