{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:02:43Z","timestamp":1787666563438,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T00:00:00Z","timestamp":1338940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the prognostic value of amp(1q21) alone and in combination with other abnormalities in newly diagnosed myeloma patients. The study group consisted of 104 patients treated with various induction regimens, mostly thalidomide based (87 patients). Amp(1q21) was detected in 49 (47.1%) of patients; in 26 (25.0%) cases, it was combined with del(13q14), in 7 (6.7%) with del(17p13) and in 15 (14.4%) with t(4;14)(p16;q32). The response rate was significantly better in amp(1q21)\u2010negative than in amp(1q21)\u2010positive patients (74.5% vs 55.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.025; complete response 18.2% vs 4.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.024). The median progression\u2010free survival (PFS) was 33.9\u2009months in patients without amp(1q21) and 10.3\u2009months with this aberration (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). The presence of additional abnormalities resulted in significantly shortened PFS when compared with patients with isolated amp(1q21): coexisting del(13q14) resulted in 7.8 vs 29.0\u2009months of PFS (<jats:italic>p<\/jats:italic>\u2009=\u20090.024) and del(17p13) resulted in 4.0 vs 24.9\u2009months of PFS (<jats:italic>p<\/jats:italic>\u2009=\u20090.034). The presence of amp(1q21) significantly influenced overall survival (OS) as well as PFS resulting in the median OS of 26.6 vs 62.4\u2009months (<jats:italic>p<\/jats:italic>\u2009=\u20090.018) in patients without amp(1q21). The presence of additional genetic abnormalities significantly affected OS when compared with patients carrying isolated amp(1q21): for del(13q14) 18.9 vs 58.4\u2009months (<jats:italic>p<\/jats:italic>\u2009=\u20090.004) and for del(17p13) 12.0 vs 46.5\u2009months (<jats:italic>p<\/jats:italic>\u2009=\u20090.036). On multivariate analysis amp(1q21), del(13q14) and del(17p13) were found to be an independent adverse predictors of shorter PFS and OS. Our results showed that the presence of amp(1q21) was associated with poor prognosis. Moreover additional genetic abnormalities made PFS and OS further shortened. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2018","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T12:14:11Z","timestamp":1338984851000},"page":"41-48","source":"Crossref","is-referenced-by-count":33,"title":["Additional genetic abnormalities significantly worsen poor prognosis associated with 1q21 amplification in multiple myeloma patients"],"prefix":"10.1002","volume":"31","author":[{"given":"Norbert","family":"Grzasko","sequence":"first","affiliation":[{"name":"Department of Haematooncology and Bone Marrow Transplantation Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Hus","sequence":"additional","affiliation":[{"name":"Department of Haematooncology and Bone Marrow Transplantation Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Pluta","sequence":"additional","affiliation":[{"name":"Department of Haematology Podkarpacie Oncology Center  Brzozow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Jurczyszyn","sequence":"additional","affiliation":[{"name":"Department of Haematology, Collegium Medicum Jagiellonian University  Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Walter\u2010Croneck","sequence":"additional","affiliation":[{"name":"Department of Haematooncology and Bone Marrow Transplantation Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Morawska","sequence":"additional","affiliation":[{"name":"Department of Haematooncology and Bone Marrow Transplantation Medical University of Lublin  Lublin 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