{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:28:31Z","timestamp":1791268111383,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T00:00:00Z","timestamp":1340150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Some patients with lymphoma have monocytosis at diagnosis, but its significance is unclear. The recently recognized subpopulation, monocytic myeloid\u2010derived suppressor cells (M\u2010MDSCs), has immunoregulatory function, suppresses host anti\u2010tumour immunity and plays a role in cancer tolerance. Data from 91 untreated patients with diffuse large B\u2010cell lymphoma (DLBCL) were evaluated for monocytosis &gt;1000\/mm<jats:sup>3<\/jats:sup> at diagnosis and its significance compared with a number of well\u2010established prognostic factors for DLBCL including age, stage, gender, B symptoms, extranodal sites, LDH and CRP levels, bone marrow involvement and International Prognostic Index (IPI) score. In 23 of these patients with DLBCL and 15 healthy controls, the proportion of M\u2010MDSCs in the peripheral blood was determined by flow cytometry. Monocytosis was found in 17.6% of the patient cohort examined. In the multivariate analysis, bone marrow involvement, IPI score and monocytosis were the only independent prognostic factors seen to be associated with decreased progression free and overall survival. Patients with DLBCL had on average increased M\u2010MDSCs counts at diagnosis compared with controls, which returned to normal after achieving remission. In conclusion, monocytosis was identified as an independent prognostic factor in DLBCL and correlated with worse overall survival. The significant increases in the M\u2010MDSCs pool observed in some of the cases examined may possibly help to explain why monocytosis is associated with poor outcome in these patients. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2019","type":"journal-article","created":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T10:12:50Z","timestamp":1340187170000},"page":"65-71","source":"Crossref","is-referenced-by-count":67,"title":["Absolute monocytosis at diagnosis correlates with survival in diffuse large B\u2010cell lymphoma\u2014possible link with monocytic myeloid\u2010derived suppressor cells"],"prefix":"10.1002","volume":"31","author":[{"given":"Tamar","family":"Tadmor","sequence":"first","affiliation":[{"name":"Hematology Unit Bnai\u2010Zion Medical Center  Haifa Israel"},{"name":"The Rappaport Faculty of Medicine Technion\u2014Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rona","family":"Fell","sequence":"additional","affiliation":[{"name":"Hematology Unit Bnai\u2010Zion Medical Center  Haifa 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