{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:21:37Z","timestamp":1773296497226,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T00:00:00Z","timestamp":1345680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an extremely rare condition that originates from dendritic cells. We report on the first case of Epstein\u2013Barr virus (EBV)\u2010driven post\u2010transplant lymphoproliferative disorder (PTLD) of donor origin in a BPDC patient post\u2010allogeneic haematopoietic stem cell transplantation (HSCT). Flow cytometry study identified a cell population CD4+\/CD56+\/CD45RA+\/CD123+\/TCL1+ suggestive of BPDCN diagnosis, which was confirmed by a lymph node biopsy (cells positive for BCL11a, BDCA\u20102, CD2AP, CD123, TCL1 and S100). Cytogenetic analysis revealed a complex karyotype: (19 metaphase) 47,XX,t(1;6)(q21;q2?5),\u201013\u2009+\u20092mar[11]\/47, XX, +21 [3]\/46,XX [5]. The patient was started on acute myeloid leukaemia (AML) induction schedule, and subsequently an allogeneic HSCT was performed. On day +36 post\u2010HSCT, bone marrow biopsy\/aspirate showed complete morphological remission, and chimerism study showed 100% donor chimera. However, on day +37, the patient was found to have enlarged cervical and supraclavicular lymphoadenopathy, splenomegaly and raised lactic dehydrogenase. EBV\u2010DNA copies in blood were elevated, consistent with a lytic cycle. A lymph node biopsy showed EBV encoded RNA and large atypical B cells (CD45dim\u2212, CD4+\/CD56+, monoclonal for k\u2010chain, CD19+\/CD20+\/CD21+\/CD22+\/CD38+\/CD43+\/CD79\u03b2\u2212\/CD5\u2212\/CD10\u2212), consistent with PTLD monomorphic type. Chimerism study showed that PTLD was of donor origin. This case together with the recent literature findings on BPDCN and PTLD are discussed. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2023","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T05:51:11Z","timestamp":1345701071000},"page":"210-213","source":"Crossref","is-referenced-by-count":10,"title":["Post\u2010transplant lymphoproliferative disease of donor origin, following haematopoietic stem cell transplantation in a patient with blastic plasmacytoid dendritic cell neoplasm"],"prefix":"10.1002","volume":"30","author":[{"given":"Andrea","family":"Piccin","sequence":"first","affiliation":[{"name":"Haematology Dept San Maurizio Regional Hospital  Bolzano South Tyrol Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Morello","sequence":"additional","affiliation":[{"name":"Haematology Dept Brescia General Hospital  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirija","family":"Svaldi","sequence":"additional","affiliation":[{"name":"Haematology Dept San Maurizio Regional Hospital  Bolzano South Tyrol Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Haferlach","sequence":"additional","affiliation":[{"name":"Institute of Munchner Leukamie Labor GMBH  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Facchetti","sequence":"additional","affiliation":[{"name":"Dept of Molecular and Translational Medicine Pathology Unit, University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Negri","sequence":"additional","affiliation":[{"name":"Pathology Dept San Maurizio Regional Hospital  Bolzano South Tyrol Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Vecchiato","sequence":"additional","affiliation":[{"name":"Dept of Transfusion Medicine San Maurizio Regional Hospital  Bolzano South Tyrol Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Fisogni","sequence":"additional","affiliation":[{"name":"Dept of Molecular and Translational Medicine Pathology Unit, University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Pusceddu","sequence":"additional","affiliation":[{"name":"Haematology Dept San Maurizio Regional Hospital  Bolzano South Tyrol Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Cortelazzo","sequence":"additional","affiliation":[{"name":"Haematology Dept San Maurizio Regional Hospital  Bolzano South Tyrol Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.026179"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07679.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-117531"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3297"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2416"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000165510"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/11360"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.4.2291"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324531"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030162"},{"issue":"12","key":"e_1_2_6_12_1","first-page":"996","article-title":"A clinical study of lymphoproliferative disorders following allogeneic hematopoietic stem cell transplantation","volume":"46","author":"Xu LP","year":"2007","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3181bb6bc2"},{"key":"e_1_2_6_14_1","first-page":"877","article-title":"Posttransplant lymphoproliferative disease in thoracic organ transplant patients: ten years of cyclosporine\u2010based immunosuppression","volume":"10","author":"Armitage JM","year":"1991","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09373.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.12.706"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.11.4154"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181de9ce0"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-12-024802"},{"issue":"8","key":"e_1_2_6_20_1","first-page":"1059","article-title":"The role of HLA mismatch, splenectomy and recipient Epstein\u2013Barr virus seronegativity as risk factors in post\u2010transplant lymphoproliferative disorder following allogeneic hematopoietic stem cell transplantation","volume":"91","author":"Sundin M","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2001.003002070.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200201270-00020"},{"issue":"1","key":"e_1_2_6_23_1","first-page":"99","article-title":"Post\u2010transplantation lymphoproliferative disorder of donor origin in a sex\u2010mismatched renal allograft as proven by chromosome in situ hybridization","volume":"11","author":"Cheung AN","year":"1998","journal-title":"Mod Pathol"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03454.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0915054107"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.12.706"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0655-0"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03922.x"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2023","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T12:13:28Z","timestamp":1700568808000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,23]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1002\/hon.2023"],"URL":"https:\/\/doi.org\/10.1002\/hon.2023","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,23]]}}}