{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:21:32Z","timestamp":1780467692914,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T00:00:00Z","timestamp":1349136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hodgkin lymphoma (HL) is one of the most common types of cancer in the young and one of the most curable forms of cancer. Therefore, there has been an increasing interest in the study of long\u2010term morbidities. The aims of the present study were to evaluate the prevalence and risk factors for impaired gonadal function in a retrospective cohort of 238 HL female survivors from Italy and Brazil and to analyse the role of oral contraceptives (OC) and GnRH\u2010analogues. Besides data collection from HL databases, a specific questionnaire was administered to collect data on gonadal function. The median age at diagnosis was 25\u2009years and the median follow\u2010up was 7\u2009years. Overall, 25% of the patients developed impaired gonadal function. Older age at diagnosis, front\u2010line therapies containing alkylating agents and more than one treatment were independent risk factors, whereas the use of OC or GnRH\u2010a reduced independently the risk of impaired gonadal function. The fertility rate among fertile survivors was low when compared with the general population. We confirmed that older age, type of front\u2010line chemotherapy and a higher number of therapies are associated with gonadal function impairment in terms of infertility and premature menopause in female HL survivors. Also, the use of GnRH\u2010a or OC was independently identified as a protective factor. Further prospective studies are needed to better understand the barriers to parenthood in HL survivors. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2029","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T11:45:20Z","timestamp":1349178320000},"page":"72-78","source":"Crossref","is-referenced-by-count":12,"title":["Risk factors for impaired gonadal function in female Hodgkin lymphoma survivors: final analysis of a retrospective multicenter joint study from Italian and Brazilian Institutions"],"prefix":"10.1002","volume":"31","author":[{"given":"Simona","family":"Falorio","sequence":"first","affiliation":[{"name":"Dipartimento di Ematologia Ospedale Civile Spirito Santo  Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Biasoli","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital and School of Medicine Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Luminari","sequence":"additional","affiliation":[{"name":"Dipartimento di Oncologia ed Ematologia Universit\u00e0 degli studi di Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Quintana","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Ematologia Ospedale Perrino  Brindisi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Musso","sequence":"additional","affiliation":[{"name":"Dipartimento di Ematologia Ospedale La Maddalena  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Dell'Olio","sequence":"additional","affiliation":[{"name":"Dipartimento di Ematologia Ospedale Casa Sollievo della Sofferenza  San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Specchia","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Ematologia Ospedale S.G. 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