{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:26:02Z","timestamp":1761895562688},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T00:00:00Z","timestamp":1352851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Angioimmunoblastic T\u2010cell lymphoma (AITL) is characterized by an aggressive clinical course and unfavourable prognosis. Refractory AITL patients have very few treatment options. Lenalidomide has previously been reported to have clinical efficacy in this setting; however, long\u2010term reports are limited. A 59\u2010year\u2010old man was referred to the hospital with fatigue, skin rash, weight loss and generalized lymphadenopathy and was diagnosed with AITL; clinical stage was IV B with bone marrow involvement. The patient had an unsatisfactory response despite three lines of conventional chemotherapy and radiotherapy. The patient received lenalidomide monotherapy (25\u2009mg once daily) on days\u20091 to 21 of every 28\u2010day cycle for six cycles, followed by maintenance therapy with six cycles of lenalidomide 15\u2009mg once daily on days\u20091 to 21 of every 28\u2010day cycle. A computed tomography scan was assessed before lenalidomide treatment, after the third cycle, at disease restaging 2\u2009months after completion of the induction phase, every 3\u2009months during the maintenance phase and every 6\u2009months during the follow\u2010up period. At the last evaluation, after a follow\u2010up of 30\u2009months, the patient maintained a clinical and radiological complete response. The treatment was well tolerated with manageable toxicity. Lenalidomide treatment demonstrated for the first time in the literature impressive and long\u2010term clinical efficacy in a heavily pretreated chemorefractory AITL patient. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2038","type":"journal-article","created":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T17:28:03Z","timestamp":1353000483000},"page":"213-217","source":"Crossref","is-referenced-by-count":10,"title":["Impressive activity of lenalidomide monotherapy in refractory angioimmunoblastic T\u2010cell lymphoma: report of a case with long\u2010term follow\u2010up"],"prefix":"10.1002","volume":"31","author":[{"given":"Alberto","family":"Fabbri","sequence":"first","affiliation":[{"name":"Unit of Hematology \u201cS. Maria alle Scotte\u201d University Hospital  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Cencini","sequence":"additional","affiliation":[{"name":"Unit of Hematology \u201cS. Maria alle Scotte\u201d University Hospital  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Pietrini","sequence":"additional","affiliation":[{"name":"Unit of Hematology \u201cS. Maria alle Scotte\u201d University Hospital  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Gozzetti","sequence":"additional","affiliation":[{"name":"Unit of Hematology \u201cS. Maria alle Scotte\u201d University Hospital  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzia","family":"Defina","sequence":"additional","affiliation":[{"name":"Unit of Hematology \u201cS. Maria alle Scotte\u201d University Hospital  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Fontanelli","sequence":"additional","affiliation":[{"name":"Unit of Hematology \u201cS. Chiara\u201d University Hospital  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Antonietta","family":"Mazzei","sequence":"additional","affiliation":[{"name":"Unit of Radiology \u201cS. Maria alle Scotte\u201d University Hospital  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Volterrani","sequence":"additional","affiliation":[{"name":"Unit of Radiology \u201cS. Maria alle Scotte\u201d University Hospital  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Bocchia","sequence":"additional","affiliation":[{"name":"Unit of Hematology \u201cS. 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