{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:24:30Z","timestamp":1700699070104},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T00:00:00Z","timestamp":1366588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immune thrombocytopenia complicates the course and impacts the outcome of non\u2010Hodgkin lymphoma (NHL\u2010ITP, non\u2010Hodgkin lymphoma\u2013immune thrombocytopenic purpura). The response to corticosteroids and\/or intravenous immune globulins is usually short lasting, but NHL\u2010ITP usually responds to anti\u2010lymphoma chemotherapy. It is not clear if this success is due to the elimination of the lymphomatous tissue or to the immunosuppressor\/immunomodulator effect of chemotherapy. Myelosuppressive anti\u2010lymphoma chemotherapy carries the risk of severe thrombocytopenia that may not respond adequately to platelet transfusion support. We report on a patient with recurrent diffuse large B\u2010cell lymphoma that coincided with immune thrombocytopenia. Both diseases completely responded to involved field radiation therapy. This supports the hypothesis that at least in some cases of NHL\u2010ITP, the lymphomatous clone secretes the anti\u2010platelet antibodies. This supports the therapeutic decision making for these patients. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2048","type":"journal-article","created":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T09:22:42Z","timestamp":1366622562000},"page":"218-220","source":"Crossref","is-referenced-by-count":5,"title":["Successful treatment of non\u2010Hodgkin lymphoma associated immune thrombocytopenia with involved field radiotherapy"],"prefix":"10.1002","volume":"31","author":[{"given":"Tanya","family":"Berrang","sequence":"first","affiliation":[{"name":"Radiation Therapy Program BC Cancer Agency \u2013 Vancouver Island Centre  Victoria BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Holloway","sequence":"additional","affiliation":[{"name":"Radiation Therapy Program BC Cancer Agency \u2013 Vancouver Island Centre  Victoria BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Systemic Therapy BC Cancer Agency \u2013 Vancouver Island Centre  Victoria BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Yee","sequence":"additional","affiliation":[{"name":"Department of Systemic Therapy BC Cancer Agency \u2013 Vancouver Island Centre  Victoria BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Pathology BC Cancer Agency \u2013 Vancouver Island Centre  Victoria BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami","family":"Kotb","sequence":"additional","affiliation":[{"name":"Department of Systemic Therapy BC Cancer Agency \u2013 Vancouver Island Centre  Victoria BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj004"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2004.11.011"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404782"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11934"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0229-4"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08825.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02113.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000144263.32248.1a"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/1042819031000103944"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197604)37:4<1999::AID-CNCR2820370451>3.0.CO;2-U"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05271.x"},{"key":"e_1_2_4_13_1","first-page":"200","article-title":"A case of malignant lymphoma producing autoantibody against platelet glycoprotein Ib","volume":"70","author":"Nobuoka A","year":"1999","journal-title":"Int J Hematol"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.033555"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.73318"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2048","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T05:03:15Z","timestamp":1700629395000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,22]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1002\/hon.2048"],"URL":"https:\/\/doi.org\/10.1002\/hon.2048","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,22]]}}}