{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T15:52:59Z","timestamp":1717084379371},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T00:00:00Z","timestamp":1376611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The translocation t(2;11)(p21;q23) is associated with <jats:italic>de novo<\/jats:italic> myelodysplastic syndromes (MDS) and has an overall frequency of approximately 1%. The outcome of MDS patients with this translocation is not clear until now, because most of the clinical data addressing the t(2;11)(p21;q23) has been collected without investigating the status of the mixed lineage leukemia (MLL) gene. In this report, we present seven new patients with MDS diagnosis and the t(2;11)(p21;q23) in bone marrow cells; all of them without MLL gene rearrangement. They were found in two databases consisting of 1185 patients of two Czech institutions. These patients tended to be younger and showed a strong male predominance. A cytological and histological assessment of bone marrow at diagnosis revealed only mild MDS with marked dysplasia in megakaryopoiesis. Similar to other primary abnormalities in MDS (e.g. deletion of 11q), the t(2;11)(p21;q23) was frequently associated with deletion of 5q. Our results stress the common clinicopathological features of this entity and indicate that the t(2;11)(p21;q23) may be associated with a good prognosis for MDS patients (median survival 72\u2009months). Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2089","type":"journal-article","created":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T22:57:21Z","timestamp":1397775441000},"page":"82-86","source":"Crossref","is-referenced-by-count":5,"title":["The translocation t(2;11)(p21;q23) without MLL gene rearrangement\u2014a possible marker of good prognosis in myelodysplastic syndrome patients"],"prefix":"10.1002","volume":"32","author":[{"given":"Pavel","family":"Dvorak","sequence":"first","affiliation":[{"name":"Institute of Medical Genetics University Hospital Pilsen  Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Lysak","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology University Hospital Pilsen  Pilsen Czech 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