{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:29:12Z","timestamp":1761895752050},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:00:00Z","timestamp":1381276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is no standard treatment for patients with gastric marginal zone B\u2010cell lymphoma of the mucosa\u2010associated lymphoid tissue (MALT lymphoma) who are resistant to, or ineligible for, anti\u2010<jats:italic>Helicobacter pylori<\/jats:italic> (anti\u2010HP) therapy. In this study, we investigated the activity of the rituximab, cyclophosphamide, vincristine and prednisone (R\u2010CVP) regimen in patients with gastric MALT lymphoma. Patients were included provided they had untreated gastric MALT lymphoma (except for anti\u2010HP therapy) and were resistant to, or ineligible for, anti\u2010HP therapy. Treatment plan consisted of six to eight 21\u2010day\u2009cycles of the R\u2010CVP chemotherapy regimen. Toxicity, response, relapse and survival were evaluated. Twenty patients (12 women and 8 men) were included in the analyses with median age of 59\u2009years. Thirteen patients (65%) had stage I tumours, and seven patients (35%) had stages II\u2013IV tumours. The overall response rate was 100%, with 19 (95%) complete responses and one (5%) partial response. Regimen toxicity was mild and mainly hematological, and no cases of gastric bleeding or perforation occurred. After a median follow\u2010up of 56.3\u2009months, three patients had relapsed, and 19 patients remained alive (specific lymphoma survival 100%), of whom 17 had no evidence of disease. In our experience, the R\u2010CVP regimen is a well\u2010tolerated and effective treatment for patients with gastric MALT lymphoma who are resistant to, or ineligible for, anti\u2010HP therapy. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2105","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:56:33Z","timestamp":1381542993000},"page":"139-144","source":"Crossref","is-referenced-by-count":11,"title":["Treatment of gastric marginal zone B\u2010cell lymphoma of the mucosa\u2010associated lymphoid tissue with rituximab, cyclophosphamide, vincristine and prednisone"],"prefix":"10.1002","volume":"32","author":[{"given":"David","family":"Aguiar\u2010Bujanda","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Hospital Universitario de Gran Canaria Dr Negrin  Las Palmas de Gran Canaria Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Llorca\u2010M\u00e1rtinez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de Gran Canaria Dr Negrin  Las Palmas de Gran Canaria 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