{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:08:14Z","timestamp":1781712494951,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T00:00:00Z","timestamp":1401321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autologous stem cell transplantation (ASCT) is a potentially curative treatment of lymphoma, but peripheral blood stem cell (PBSC) mobilization fails in some patients. PBSC mobilizing agents have recently been proved to improve the PBSC yield after a prior mobilization failure. Predictive parameters of mobilization failure allowing for a preemptive, more cost\u2010effective use of such agents during the first mobilization attempt are still poorly defined, particularly during mobilization with chemotherapy\u2009+\u2009granulocyte colony\u2010stimulating factor (G\u2010CSF). We performed a retrospective analysis of a series of lymphoma patients who were candidates for ASCT, to identify factors influencing PBSC mobilization outcome. Premobilization parameters\u2014age, histology, disease status, mobilizing protocol, and previous treatments\u2014as well as white blood cell (WBC) and PBSC kinetics, markers potentially able to predict failure during the ongoing mobilization attempt, were analyzed in 415 consecutive mobilization procedures in 388 patients. We used chemotherapy\u2009+\u2009G\u2010CSF in 411 (99%) of mobilization attempts and PBSC collection failed (&lt;2\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> CD34+ PBSC\/kg) in 13%. Multivariable analysis showed that only a low CD34+ PBSC count and CD34+ PBSC\/WBC ratio, together with the use of nonplatinum\u2010containing chemotherapy, independently predicted mobilization failure. Using these three parameters, we established a scoring system to predict risk of failure during mobilization ranging from 2 to 90%, thus allowing a selective use of a preemptive mobilization policy. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2148","type":"journal-article","created":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T09:44:44Z","timestamp":1401356684000},"page":"125-132","source":"Crossref","is-referenced-by-count":19,"title":["PBSC mobilization in lymphoma patients: analysis of risk factors for collection failure and development of a predictive score based on the kinetics of circulating CD34+ cells and WBC after chemotherapy and G\u2010CSF mobilization"],"prefix":"10.1002","volume":"33","author":[{"given":"Giuseppe","family":"Rossi","sequence":"first","affiliation":[{"name":"Division of Hematology Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Skert","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Unit, Spedali Civili University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Morello","sequence":"additional","affiliation":[{"name":"Division of Hematology Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camillo","family":"Almici","sequence":"additional","affiliation":[{"name":"Stem Cell Collection Unit Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Arcaini","sequence":"additional","affiliation":[{"name":"Division of Hematology, Fondazione IRCCS Policlinico San Matteo University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Basilico","sequence":"additional","affiliation":[{"name":"Division of Hematology Niguarda Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Cavalli","sequence":"additional","affiliation":[{"name":"Division of Hematology Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Botto","sequence":"additional","affiliation":[{"name":"Division of Hematology AOU San Giovanni Battista  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Castelli","sequence":"additional","affiliation":[{"name":"Division of Hematology Amedeo Avogadro University of Eastern Piedmont  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmatteo","family":"Pica","sequence":"additional","affiliation":[{"name":"Division of Hematology\/BMT Unit Azienda Ospedaliera Universitaria San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Ripamonti","sequence":"additional","affiliation":[{"name":"Division of Hematology, Fondazione IRCCS Policlinico San Matteo University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Salvi","sequence":"additional","affiliation":[{"name":"Division of Hematology Ospedale Civile  Alessandria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo M.","family":"Carella","sequence":"additional","affiliation":[{"name":"Division of Hematology\/BMT Unit Azienda Ospedaliera Universitaria San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Gaidano","sequence":"additional","affiliation":[{"name":"Division of Hematology Amedeo Avogadro University of Eastern Piedmont  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Levis","sequence":"additional","affiliation":[{"name":"Division of Hematology Ospedale Civile  Alessandria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Nosari","sequence":"additional","affiliation":[{"name":"Division of Hematology Niguarda Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Russo","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Unit, Spedali Civili University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Vitolo","sequence":"additional","affiliation":[{"name":"Division of Hematology AOU San Giovanni Battista  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.2.509"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.6.1360"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703364"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702531"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21400"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200061"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.11.012"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.7209"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.07.014"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.119"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.249"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2012.03.011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.11.028"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-012-1411-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03349.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/146532401753156368"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-4541-9"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-77244-8"},{"key":"e_1_2_6_20_1","volume-title":"Statistical modelling of complex medical data","author":"D'Agostino RB","year":"2004"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.82"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703729"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.133"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.74"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.217"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.236"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21206"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.08.010"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03206.x"},{"key":"e_1_2_6_30_1","first-page":"94","article-title":"Early measurement of CD34+ cells in peripheral blood after cyclophosphamide and granulocyte colony\u2010stimulating factor treatment predicts later CD34+ mobilisation failure and is a possible criterion for guiding \" on demand\" use of plerixafor","volume":"11","author":"Milone G","year":"2013","journal-title":"Blood Transfus"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.802783"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22179"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2148","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T04:21:16Z","timestamp":1696479676000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,29]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1002\/hon.2148"],"URL":"https:\/\/doi.org\/10.1002\/hon.2148","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,29]]}}}