{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:24:48Z","timestamp":1780629888558,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,8,18]],"date-time":"2014-08-18T00:00:00Z","timestamp":1408320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Translocations of the histone\u2010lysine <jats:italic>N<\/jats:italic>\u2010methyltransferase 2A (<jats:italic>KMT2A<\/jats:italic>) gene, formerly known as myeloid lymphoid leukemia\/mixed\u2010lineage leukemia gene, are commonly associated with high\u2010risk <jats:italic>de novo<\/jats:italic> or therapy\u2010associated B\u2010cell and T\u2010cell lymphoblastic leukemias and myeloid neoplasms. Rare B\u2010cell non\u2010Hodgkin lymphomas harboring <jats:italic>KMT2A<\/jats:italic> translocations have been reported, but information regarding the clinical behavior of such cases is limited. Here, we describe two extranodal diffuse large B\u2010cell lymphomas (DLBCLs): a primary thyroid DLBCL and a large cell transformation of a splenic marginal zone lymphoma, which displayed complex karyotypes and translocations involving chromosome 11q23 targeting the <jats:italic>KMT2A<\/jats:italic> gene. The pathological and clinical characteristics of these cases are discussed in the context of previously reported lymphomas associated with different types of <jats:italic>KMT2A<\/jats:italic> genetic aberrations. In contrast to the poor clinical outcomes of patients with acute leukemias and myeloid neoplasms associated with <jats:italic>KMT2A<\/jats:italic> translocations, patients with B\u2010cell non\u2010Hodgkin lymphomas, exhibiting similar translocations, appear to respond well to immunochemotherapy. Our findings add to the growing list of histone methyltransferase genes deregulated in DLBCL and highlight the diversity of mechanisms, altering the function of epigenetic modifier genes in lymphomas.<\/jats:p>","DOI":"10.1002\/hon.2158","type":"journal-article","created":{"date-parts":[[2014,8,18]],"date-time":"2014-08-18T07:42:56Z","timestamp":1408347776000},"page":"239-246","source":"Crossref","is-referenced-by-count":13,"title":["<i>MLL<\/i>\/<i>KMT2A<\/i> translocations in diffuse large B\u2010cell lymphomas"],"prefix":"10.1002","volume":"33","author":[{"given":"Tatyana","family":"Gindin","sequence":"first","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center and New York Presbyterian Hospital  New York NY 10032 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vundavalli","family":"Murty","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center and New York Presbyterian Hospital  New York NY 10032 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bachir","family":"Alobeid","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center and New York Presbyterian Hospital  New York NY 10032 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6250-048X","authenticated-orcid":false,"given":"Govind","family":"Bhagat","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center and New York Presbyterian Hospital  New York NY 10032 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2011.04.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0542"},{"key":"e_1_2_7_4_1","unstructured":"SwerdlowSH CE HarrisNL JaffeES PileriSA ThieleJ VardimanJW.WHO classification of tumours of haematopoietic and lymphoid tissues. 4 ed. 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