{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:25:04Z","timestamp":1790673904941,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T00:00:00Z","timestamp":1416355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of PET in patients with marginal zone B cell lymphoma (MZL) is controversial because of variability of fluorodeoxyglucose (FDG) avidity. We analyzed 40 PET\/CT in 25 consecutive patients to compare its performance with CT at staging and as a first\u2010line response assessment. Sensitivity of PET\/CT and CT was 96 and 76%. Mean standard uptake value was 6.1, 6.9 and 3.4 (<jats:italic>p<\/jats:italic>\u2009=\u20090.3) in nodal, extranodal and splenic subtypes, respectively. Of 17 patients (extranodal: <jats:italic>n<\/jats:italic>\u2009=\u20099; nodal: <jats:italic>n<\/jats:italic>\u2009=\u20096; splenic subtype: <jats:italic>n<\/jats:italic>\u2009=\u20092) with both imaging tests available at diagnosis, 8 (47%) had more involved areas with PET\/CT than with CT, 75% of which were extranodal lesions. PET\/CT resulted in upstaging of five patients although treatment of only two of them was changed. Responses of 15 patients with post\u2010treatment PET\/CT were the following: 9 negative and 6 positive of which 3 were isolated residual lesions. Progression was documented in two of these three patients. Response was also assessed by CT in 11 patients. Discrepancies were found in three: Two were in complete remission by CT while PET\/CT detected localized residual disease; another patient was in partial remission by CT, whereas PET\/CT showed only one positive lesion. Two of these three patients relapsed. Patients with negative post\u2010treatment PET\/CT did not relapse. With a median follow\u2010up of 50\u2009months (10\u2013152\u2009months), 3\u2010year overall survival was 100 and 80% for patients with negative and positive post\u2010treatment PET\/CT (<jats:italic>p<\/jats:italic>\u2009=\u20090.2). Three\u2010year disease\u2010free survival was 86%; the negative predictive value (NPV) was 100%, and the positive predictive value (PPV) was 83.3%. Although a larger number of patients will be required to further confirm these data, we can conclude that PET\/CT is a useful imaging tool for both staging and response assessment in patients with nodal and extranodal MZL as a result of its high sensitivity, NPV and PPV. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2181","type":"journal-article","created":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T08:09:14Z","timestamp":1416384554000},"page":"151-158","source":"Crossref","is-referenced-by-count":45,"title":["Role of 18F\u2010FDG\u2010PET\/CT in the management of marginal zone B cell lymphoma"],"prefix":"10.1002","volume":"33","author":[{"given":"Estrella","family":"Carrillo\u2010Cruz","sequence":"first","affiliation":[{"name":"Department of Hematology Instituto de Biomedicina de Sevilla (IBIS)\/Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor A.","family":"Mar\u00edn\u2010Oyaga","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Instituto de Biomedicina de Sevilla (IBIS)\/Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla  Seville 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