{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:43:20Z","timestamp":1779918200780,"version":"3.53.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T00:00:00Z","timestamp":1417564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Allogeneic transplantation is the only potentially curative strategy for myelofibrosis, even in the era of new drugs that so far only mitigate symptoms. The choice to proceed to allogeneic transplantation is based on several variables including age, disease phase, degree of splenomegaly, donor availability, comorbidities and iron overload. These factors, along with conditioning regimen and time to transplantation, may influence the outcome of ASCT. We report 14 patients affected by myelofibrosis with a median age of 57\u2009years (range, 41\u201376) receiving a treosulfan\u2010fludarabine based reduced toxicity conditioning. Patients (pts) received a stem cell transplantation from an HLA identical (<jats:italic>n<\/jats:italic>\u2009=\u200910) or matched unrelated donor (<jats:italic>n<\/jats:italic>\u2009=\u20094). All pts had a complete myeloablation followed by engraftment and in 12 out of 13 evaluated pts donor chimerism was 100% at 1\u2009month. In most cases a reduction of splenomegaly and a reduction (or resolution) of bone marrow fibrosis was observed. After a median follow\u2010up of 39\u2009months (range, 3\u2013106), the 3\u2010year probability of overall survival and disease free survival was 54\u2009+\/\u2212\u200914% and 46\u2009+\/\u2212\u200914%, respectively. The cumulative incidence of non\u2010relapse mortality at 2\u2009years was 39\u2009+\/\u2212\u200915%. Causes of non\u2010relapse mortality were: infection (<jats:italic>n<\/jats:italic>\u2009=\u20092), GvHD (<jats:italic>n<\/jats:italic>\u2009=\u20092) and haemorrhage (<jats:italic>n<\/jats:italic>\u2009=\u20091).<\/jats:p><jats:p>We can conclude that a treosulfan and fludarabine based conditioning has a potent myeloablative and anti\u2010disease activity although non\u2010relapse mortality remains high in this challenging clinical setting. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2183","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T01:58:52Z","timestamp":1417658332000},"page":"154-160","source":"Crossref","is-referenced-by-count":8,"title":["Treosulfan based reduced toxicity conditioning followed by allogeneic stem cell transplantation in patients with myelofibrosis"],"prefix":"10.1002","volume":"34","author":[{"given":"Simone","family":"Claudiani","sequence":"first","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Unit IRCCS San Raffaele Scientific Institute  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Marktel","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Unit IRCCS San Raffaele Scientific Institute  Milano 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