{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T08:52:23Z","timestamp":1777107143859,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T00:00:00Z","timestamp":1418169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple myeloma (MM) is a hematologic neoplasm characterized by plasma tumor cell proliferation in the bone marrow. It's a rare malignancy before a 40\u2010year\u2010old and it is extremely uncommon during pregnancy. We report the case of a 37\u2010year\u2010old woman with a newly diagnosed IgG \u03bb MM (Durie\u2013Salmon stage IIIA, International Staging System II and good prognosis cytogenetic) at the 27th week of her pregnancy. Our management during pregnancy, the delivery, and initiation of anti\u2010myeloma treatment with bortezomib, lenalidomide, and dexamethasone are published. There are a few reviews reporting the most common features and management of MM during pregnancy. We perform a comprehensive review of all 32 cases reported between 1965 and 2014 in which a MM was diagnosed during pregnancy including score, cytogenetic results, labor characteristics, and response to therapy. About 53% of pregnant women did not start treatment before partum. Cesarean section was the most common form of delivery (82%). About 88% of newborns were healthy, although most of them were premature (73%). Management of a MM diagnosed during pregnancy should be based on the presence of myeloma\u2010related organ damage to secure survival of the mother without fetal adverse effects related to treatment. Serial fetal ultrasound may be helpful in order to avoid complications. The cesarean section may be preferred depending on maternal and fetus prognosis. Whole\u2010body diffusion\u2010weighted imaging minimal response could be an appropriate technique to discard plasmacytomas during pregnancy in critical situations such as the appearance of symptoms of spinal cord compression. Therapeutic choices should be agreed with the pregnant after a thorough discussion of the prognostic factors of the disease and the potential risk for the fetus and the patient. While awaiting partum, dexamethasone is a non\u2010toxic treatment. Triple therapy including a proteasome inhibitor should be started quickly after delivery. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2184","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T11:45:44Z","timestamp":1418211944000},"page":"108-114","source":"Crossref","is-referenced-by-count":9,"title":["\u2018Management multiple myeloma during pregnancy: a case report and review\u2019"],"prefix":"10.1002","volume":"34","author":[{"given":"Valentin","family":"Caba\u00f1as\u2010Perianes","sequence":"first","affiliation":[{"name":"Department of Hematology Virgen de la Arrixaca University Hospital  Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maribel","family":"Macizo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Virgen de la Arrixaca University Hospital  Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Salido","sequence":"additional","affiliation":[{"name":"Department of Hematology Virgen de la 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Isabel","family":"Mu\u00f1oz\u2010Garcia","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis Virgen de la Arrixaca University Hospital  Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Martinez\u2010Villanueva","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis Virgen de la Arrixaca University Hospital  Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Mu\u00f1oz\u2010Esparza","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Virgen de la Arrixaca University Hospital  Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florentina","family":"Guzm\u00e1n\u2010Aroca","sequence":"additional","affiliation":[{"name":"Department of Radiology Virgen de la Arrixaca University Hospital  Murcia 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