{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:29:12Z","timestamp":1740104952622,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007359","name":"Fondazione Banco di Sardegna","doi-asserted-by":"crossref","award":["Programma 2010-2012"],"award-info":[{"award-number":["Programma 2010-2012"]}],"id":[{"id":"10.13039\/100007359","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Italian Association for Research on Cancer","award":["IG 11855"],"award-info":[{"award-number":["IG 11855"]}]},{"name":"Itallan Ministry for Educaiton, University and Research","award":["PRIN 2007 prot.2007WEJLZB, PRIN 2009 prot. 20092ZELR2"],"award-info":[{"award-number":["PRIN 2007 prot.2007WEJLZB, PRIN 2009 prot. 20092ZELR2"]}]},{"DOI":"10.13039\/501100009873","name":"Regione Autonoma della Sardegna","doi-asserted-by":"crossref","award":["LR7 CRP-59812\/2012"],"award-info":[{"award-number":["LR7 CRP-59812\/2012"]}],"id":[{"id":"10.13039\/501100009873","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genes encoding for arylamine <jats:italic>N<\/jats:italic>\u2010acetyltransferase 1 and 2 (NAT1 and NAT2) have been investigated with alternate findings in relation to risk of non\u2010Hodgkin lymphoma (NHL). We tested functional haplotype\u2010based NAT1 and NAT2 gene polymorphisms in relation to risk of lymphoma overall and its major B cell subtypes, diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL) and chronic lymphocytic leukaemia (CLL). We used allele specific primers and multiplex PCR to detect NAT1 and NAT2 haplotypes in 248 patients with incident lymphoma and 208 population controls. We inferred the NAT1 rapid and slow acetylator and the NAT2 rapid, intermediate or slow acetylator phenotype, based on published functional data on the respective genotypes. Odds ratios and 95% confidence intervals (95% CIs) for lymphoma, B\u2010NHL, DLBCL, FL, CLL, and other B\u2010NHL combined associated with the inferred rapid NAT1 acetylator and with the intermediate and slow NAT2 acetylator phenotypes were estimated with unconditional and polytomous logistic regression analysis, adjusting for age, gender and education. NAT1 rapid acetylators showed a 2.8\u2010fold excess risk (95% CI 1.5\u20135.2) for lymphoma (all subtypes combined). Risk was highest for CLL and FL, with significant heterogeneity detected across subtypes. Risk also increased with decreasing NAT2 acetylating capacity with no heterogeneity detected across B cell lymphoma subtypes. Risks did not vary by gender. Although poor statistical power was a major limitation in our study, larger studies and pooled analyses are warranted to test whether NAT1 and NAT2 gene polymorphisms might modulate risk of specific lymphoma subtypes through the varying metabolic activity of their products. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2193","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T08:32:40Z","timestamp":1424161960000},"page":"79-83","source":"Crossref","is-referenced-by-count":2,"title":["<i>N<\/i>\u2010acetyltransferase polymorphisms are associated with risk of lymphoma subtypes"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8256-7614","authenticated-orcid":false,"given":"Pierluigi","family":"Cocco","sequence":"first","affiliation":[{"name":"Department of Public Health Clinical and Molecular Medicine Occupational Health Section University of Cagliari  Monserrato Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariagrazia","family":"Zucca","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Cytomorphology Section University of Cagliari  Monserrato Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Sanna","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Cytomorphology Section University of Cagliari  Monserrato Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giannina","family":"Satta","sequence":"additional","affiliation":[{"name":"Department of Public Health Clinical and Molecular Medicine Occupational Health Section University of Cagliari  Monserrato Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tinucia","family":"Nonne","sequence":"additional","affiliation":[{"name":"Department of Public Health Clinical and Molecular Medicine Occupational Health Section University of Cagliari  Monserrato Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Angelucci","sequence":"additional","affiliation":[{"name":"Unit of Haematology A. Businco Oncology Hospital  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attilio","family":"Gabbas","sequence":"additional","affiliation":[{"name":"Department of Public Health Clinical and Molecular Medicine Occupational Health Section University of Cagliari  Monserrato Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Rais","sequence":"additional","affiliation":[{"name":"Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Malpeli","sequence":"additional","affiliation":[{"name":"ARC\u2010NET Research Centre and Department of Pathology and Diagnostics University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Campagna","sequence":"additional","affiliation":[{"name":"Department of Public Health Clinical and Molecular Medicine Occupational Health Section University of Cagliari  Monserrato Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Scarpa","sequence":"additional","affiliation":[{"name":"ARC\u2010NET Research Centre and Department of Pathology and Diagnostics University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"G Ennas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Cytomorphology Section University of Cagliari  Monserrato Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000215071.59836.29"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21113"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-012-0098-4"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj187"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm121"},{"key":"e_1_2_5_7_1","first-page":"29","article-title":"Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms","volume":"9","author":"Hein DW","year":"2000","journal-title":"Cancer Epidemiol. 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