{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:48:27Z","timestamp":1764510507688},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T00:00:00Z","timestamp":1426636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In relapsed or refractory non\u2010Hodgkin lymphoma (NHL), allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) provides graft\u2010versus\u2010lymphoma activity resulting in fewer incidences of relapse. However, therapy\u2010related mortality (TRM) remains an important challenge. We attempted to introduce our reduced\u2010intensity conditioning (RIC) regimen. From 2007 to 2013, we treated 28 relapsed or refractory NHLs with allo\u2010HSCT. All were pre\u2010conditioned with fludarabine [FLU, 180\u2009mg\/body surface area (BSA)\/6\u2009days] and melphalan (MEL, 70\u2009mg\/BSA\/1\u2009day); 25 (all but 3) were additionally treated with total body irradiation (TBI, 800\u2009cGy\/4Fx\/2\u2009days). Peripheral blood stem cells were collected from matched siblings (<jats:italic>n<\/jats:italic>\u2009=\u200910) or suitably matched unrelated (<jats:italic>n<\/jats:italic>\u2009=\u200918) donors. There were eight diffuse large B\u2010cell lymphomas, seven peripheral T\u2010cell lymphoma not otherwise specified, give lymphoblastic lymphomas, two mantle cell lymphomas, and six various other lymphomas. Of these patients, 10 relapsed after auto\u2010HSCT, 5 relapsed after chemotherapy, and 13 were refractory lymphomas. After allo\u2010HSCT, complete remission was achieved in 22 (78.5%) patients. After a median follow\u2010up of 24.8\u2009months, 3\u2010year overall survival and disease\u2010free survival were 62.4 and 59.2% and the 3\u2010year TRM and relapse incidence were 14.9 and 28.6% respectively. Acute and chronic graft\u2010versus\u2010host diseases (GVHDs) were identified in 17 (\u2265Grade II in 12 patients) and 18 patients respectively, and the group with chronic GVHD showed favourable survival outcomes. In relapsed or refractory NHL, RIC\u2010allo\u2010HSCT using FLU\u2009+\u2009MEL\u2009+\u2009800\u2009cGy TBI showed favourable survival outcomes with acceptable TRM and relapse incidence. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2201","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T07:38:39Z","timestamp":1426664319000},"page":"17-24","source":"Crossref","is-referenced-by-count":8,"title":["Allogeneic stem cell transplantation using lymphoablative rather than myeloablative conditioning regimen for relapsed or refractory lymphomas"],"prefix":"10.1002","volume":"35","author":[{"given":"Jae\u2010Ho","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Hematology Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, The Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Woo","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Hematology Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, The Catholic University of Korea  Seoul 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